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9 p, 634.4 KB Cortical atrophy and amyloid and tau deposition in Down syndrome : A longitudinal study / Padilla, Concepción (Institut d'Investigació Biomèdica Sant Pau) ; Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ; Walpert, Madeleine J. (University of Cambridge. Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry) ; Hong, Young T. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ; Fryer, Tim D. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ; Coles, Jonathan (University of Cambridge. Division of Anaesthesia. Department of Medicine) ; Aigbirhio, Franklin I. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ; Hartley, Sigan L. (University of Wisconsin-Madison. Waisman Center) ; Cohen, Ann (University of Pittsburgh. Department of Psychiatry) ; Tudorascu, Dana L. (University of Pittsburgh. Department of Psychiatry) ; Christian, Bradley T. (University of Wisconsin-Madison. Waisman Center) ; Handen, Benjamin L. (University of Pittsburgh. Department of Psychiatry) ; Klunk, William E. (University of Pittsburgh. Department of Psychiatry) ; Holland, Anthony John (Cambridgeshire and Peterborough NHS Foundation Trust. Fulbourn Hospital) ; Zaman, Shahid H. (Cambridgeshire and Peterborough NHS Foundation Trust. Fulbourn Hospital)
Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at time point 1 (TP1) could predict cortical thickness change at time point 2 (TP2). [...]
2022 - 10.1002/dad2.12288
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 14 Núm. 1 (2022) , p. e12288  

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