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10 p, 1.3 MB Coordinated local RNA overexpression of complement induced by interferon gamma in myositis / Casal-Dominguez, Maria (Johns Hopkins University School of Medicine) ; Pinal-Fernandez, Iago (Johns Hopkins University School of Medicine) ; Pak, Katherine (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ; Muñoz-Braceras, Sandra (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ; Milisenda, Jose C. (Hospital Clínic i Provincial de Barcelona) ; Torres-Ruiz, Jiram (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Dell'Orso, Stefania (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ; Naz, Faiza (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ; Gutierrez-Cruz, Gustavo (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ; Duque-Jaimez, Yaiza (Hospital Clínic i Provincial de Barcelona) ; Matas-Garcia, Ana (Hospital Clínic i Provincial de Barcelona) ; Valls-Roca, Laura (Hospital Clínic i Provincial de Barcelona) ; Garrabou, Glòria (Hospital Clínic i Provincial de Barcelona) ; Trallero-Araguas, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Walitt, Brian (National Institute of Neurological Disorders and Stroke) ; Christopher-Stine, Lisa (Johns Hopkins University School of Medicine) ; Lloyd, Thomas E. (Johns Hopkins University School of Medicine) ; Paik, Julie J. (Johns Hopkins University School of Medicine) ; Albayda, Jemima (Johns Hopkins University School of Medicine) ; Corse, Andrea (Johns Hopkins University School of Medicine) ; Grau, Josep Maria (Hospital Clínic i Provincial de Barcelona) ; Selva O'Callaghan, Albert (Universitat Autònoma de Barcelona) ; Mammen, Andrew L. (Johns Hopkins University School of Medicine)
Complement proteins are deposited in the muscles of patients with myositis. However, the local expression and regulation of complement genes within myositis muscle have not been well characterized. In this study, bulk RNA sequencing (RNAseq) analyses of muscle biopsy specimens revealed that complement genes are locally overexpressed and correlate with markers of myositis disease activity, including the expression of interferon-gamma (IFN γ)-induced genes. [...]
2023 - 10.1038/s41598-023-28838-z
Scientific reports, Vol. 13 (february 2023)  
Detailed record - Creative Commons

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