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13 p, 5.7 MB High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation / Rico, Daniel (Newcastle University) ; Kent, Daniel (Newcastle University) ; Karataraki, Nefeli (Newcastle University) ; Mikulasova, Aneta (Newcastle University) ; Berlinguer-Palmini, Ronaldo (Newcastle University) ; Walker, Brian A. (Indiana University) ; Javierre, B. M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Russell, Lisa J. (Newcastle University) ; Brackley, Chris A. (University of Edinburgh)
Genomic rearrangements are known to result in proto-oncogene deregulation in many cancers, but the link to 3D genome structure remains poorly understood. Here, we used the highly predictive heteromorphic polymer (HiP-HoP) model to predict chromatin conformations at the proto-oncogene CCND1 in healthy and malignant B cells. [...]
2022 - 10.1101/gr.276028.121
Genome research, Vol. 32 Núm. 8 (july 2022) , p. 1355-1366  

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