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16 p, 3.7 MB Altered brain metabolome is associated with memory impairment in the rTG4510 mouse model of tauopathy / Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau) ; Wasek, Brandi (Baylor Scott & White Research Institute) ; Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ; Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Harmon, Clinton (Baylor Scott & White Research Institute) ; Arning, Erland (Baylor Scott & White Research Institute) ; Bottiglieri, Teodoro (Baylor Scott & White Research Institute) ; Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau leads to neurodegeneration and cognitive impairment remain unknown. [...]
2020 - 10.3390/metabo10020069
Metabolites, Vol. 10 Núm. 2 (february 2020) , p. 69  

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1 Wasek, Brandi
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