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Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient
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Wheatley, Rachel M. (University of Oxford, Department of Biology) ;
Caballero, Julio Diaz (University of Oxford, Department of Biology) ;
van der Schalk, Thomas E. (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
De Winter, Fien H. R. (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Shaw, Liam P. (University of Oxford, Department of Biology) ;
Kapel, Natalia (University of Oxford, Department of Biology) ;
Recanatini, Claudia (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Kluytmans, Jan (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Esser, Mark (Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Oliver, Antonio (Institut d'Investigació Sanitària Illes Balears, Hospital Universitari Son Espases) ;
Kumar-Singh, Samir (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Craig MacLean, R. (University of Oxford, Department of Biology)
Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung Pseudomonas aeruginosa populations in an intensively sampled ICU patient using a combination of genomics, isolate phenotyping, host immunity profiling, and clinical data. [...]
2022 -  10.1038/s41467-022-34101-2
Nature communications, Vol. 13 (november 2022)
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