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1.
13 p, 1.9 MB Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A systematic review and meta-analysis / Hegen, Harald (Medical University of Innsbruck) ; Walde, Janette (University of Innsbruck) ; Berek, Klaus (University of Innsbruck) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Gnanapavan, Sharmilee (Queen Mary University of London) ; Kaplan, Batia (Sheba Medical Center (Israel)) ; Khalil, Michael (Medical University of Graz) ; Saadeh, Ruba (Clínica Mayo) ; Teunissen, Charlotte E (Vrije Universiteit) ; Tumani, Hayrettin (University of Ulm) ; Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ; Willrich, Maria Alice V (Clínica Mayo) ; Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ; Deisenhammer, Florian ; Universitat Autònoma de Barcelona
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. [...]
2022 - 10.1177/13524585221134213
Multiple sclerosis, Vol. 29 (december 2022) , p. 169-181  
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2.
14 p, 1.1 MB Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A consensus statement / Hegen, Harald (Medical University of Innsbruck) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Gnanapavan, Sharmilee (Queen Mary University of London) ; Kaplan, Batia (Sheba Medical Center) ; Khalil, Michael (Medical University of Graz) ; Saadeh, Ruba (Mayo Clinic (Rochester)) ; Teunissen, Charlotte E (Amsterdam UMC) ; Tumani, Hayrettin (University of Ulm) ; Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ; Willrich, Maria Alice V (Mayo Clinic) ; Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ; Deisenhammer, Florian (Medical University of Innsbruck) ; Universitat Autònoma de Barcelona
Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. [...]
2022 - 10.1177/13524585221134217
Multiple sclerosis, Vol. 29 (december 2022) , p. 182-195  
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