Home > Search Results: Yurista, Salva R.
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10 p, 1.1 MB Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes / Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Santiago Vacas, Evelyn (Universitat Autònoma de Barcelona. Departament de Medicina) ; Yurista, Salva R. (Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands) ; Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Packer, Milton (Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas) ; Heymans, Stephane (Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands) ; Zannad, Faiez (Université de Lorraine. Centre d'Investigation Clinique Plurithématique) ; Butler, Javed (Department of Medicine, University of Mississippi, Jackson, Mississippi) ; Pascual-Figal, Domingo (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ; Lax, Antonio (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ; Núñez, Julio (Hospital Clínic Universitari (València)) ; de Boer, Rudolf A.. (Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-hydrogen exchanger (NHE)-1 co-transporter with 94. [...]
2019 - 10.1016/j.jacbts.2019.07.010
JACC: Basic to Translational Science, Vol. 4 Num. 7 (November 2019) , p. 831-840  
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1 Yurista, S.R.
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