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Resultados globales: 6 registros encontrados en 0.01 segundos.
Artículos, Encontrados 6 registros
Artículos Encontrados 6 registros  
1.
25 p, 6.2 MB Poly(Adp-ribose) binding and macroh2a mediate recruitment and functions of kdm5a at dna lesions / Kumbhar, Ramhari (University of Texas at Austin) ; Sanchez, Anthony (University of Texas at Austin) ; Perren, Jullian (University of Texas at Austin) ; Gong, Fade (Baylor College of Medicine) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Medina, Frank (University of Texas at Austin) ; Devanathan, Sravan K. (University of Texas at Austin) ; Xhemalce, Blerta (University of Texas at Austin) ; Matouschek, Andreas (University of Texas at Austin) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buck-Koehntop, Bethany A. (University of Utah) ; Miller, Kyle M. (University of Texas at Austin) ; Universitat Autònoma de Barcelona
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. [...]
2021 - 10.1083/jcb.202006149
The journal of cell biology, Vol. 220 Núm. 7 (2021) , p. e202006149  
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2.
15 p, 5.0 MB 3D chromatin remodelling in the germ line modulates genome evolutionary plasticity / Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Burden, Frances (University of Kent. School of Bioscience) ; Doddamani, Dadakhalandar (University of Kent. School of Bioscience) ; Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Leach, Emma (University of Kent. School of Bioscience) ; Marín-García, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marin Gual, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gubern Burset, Albert (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Vara González, Covadonga (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Paytuví-Gallart, Andreu (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ellis, Peter J. I. (University of Kent. School of Bioscience) ; Farré, Marta (University of Kent. School of Bioscience) ; Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Chromosome folding has profound impacts on gene regulation, whose evolutionary consequences are far from being understood. Here we explore the relationship between 3D chromatin remodelling in mouse germ cells and evolutionary changes in genome structure. [...]
2022 - 10.1038/s41467-022-30296-6
Nature communications, Vol. 13 (May 2022) , art. 2608  
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3.
14 p, 6.4 MB ATR is required to complete meiotic recombination in mice / Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rojas, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fuentes Lazaro, Judit (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas) ; Garcia-Caldés, Montserrat (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature communications, Vol. 9 (2018) , art. 2622  
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4.
12 p, 7.0 MB ATR is a multifunctional regulator of male mouse meiosis / Widger, Alexander (The Francis Crick Institute) ; Mahadevaiah, Shantha K. (Francis Crick Institute) ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Elinati, Elias (The Francis Crick Institute) ; Zohren, Jasmin (The Francis Crick Institute) ; Hirota, Takayuki (The Francis Crick Institute) ; Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Stanzione, Marcello (TU Dresden. Faculty of Medicine) ; Ojarikre, Obah (The Francis Crick Institute) ; Maciulyte, Valdone (The Francis Crick Institute) ; De Rooij, Dirk G.. (University of Amsterdam. Center for Reproductive Medicine) ; Tóth, Attila (TU Dresden. Faculty of Medicine) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Turner, James M. A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature communications, Vol. 9 (2018) , art. 2621  
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5.
24 p, 25.7 MB p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes / Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castillo Ècija, Helena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845  
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6.
27 p, 21.8 MB The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes / Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017  
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