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16 p, 3.0 MB |
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
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Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Casano-Sancho, Paula (Hospital Sant Joan de Déu (Manresa)) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Sesmilo, Gemma (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Marcos-Ruiz, Jennifer (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez-Lloveras, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rueda-Pujol, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aulinas, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Alberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Simó-Servat, Andreu (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Muñoz, Fernando (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rico, Marta (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ibáñez-Domínguez, Javier (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Cordero Asanza, Esteban (Hospital Universitari Vall d'Hebron) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Different medical therapies have been developed for pituitary adenomas. However, Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNET) have shown little response to them. Furthermore, epithelial-mesenchymal transition (EMT) has been linked to resistance to medical treatment in a significant number of tumors, including pituitary adenomas. [...]
2023 -  10.3389/fendo.2023.1129213
Frontiers in Endocrinology, Vol. 14 (march 2023)
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16 p, 4.5 MB |
Mapping the Interface of a GPCR Dimer : A Structural Model of the A Adenosine and D Dopamine Receptor Heteromer
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Borroto-Escuela, Dasiel O. (Karolinska Institutet (Estocolm, Suècia) ;
Rodriguez, David (Science for Life Laboratory, Stockholm University) ;
Romero-Fernandez, Wilber (Uppsala University) ;
Kapla, Jon (Uppsala University) ;
Jaiteh, Mariama (Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University) ;
Ranganathan, Anirudh (Stockholm University) ;
Lazarova, Tzvetana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fuxe, Kjell (Karolinska Institutet (Estocolm, Suècia)) ;
Carlsson, Jens (Uppsala University)
The A adenosine (AR) and D dopamine (DR) receptors form oligomers in the cell membrane and allosteric interactions across the AR-DR heteromer represent a target for development of drugs against central nervous system disorders. [...]
2018 - 10.3389/fphar.2018.00829
Frontiers in Pharmacology, Vol. 9 (august 2018)
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3.
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18 p, 1.7 MB |
Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A-Dopamine D Receptor Heterotetramers and Adenylyl Cyclase
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Ferré, Sergi (National Institutes of Health, Baltimore, United States) ;
Bonaventura, Jordi (National Institutes of Health, Baltimore, United States) ;
Zhu, Wendy (Circuit Therapeutics, Menlo Park, United States) ;
Hatcher-Solis, Candice (National Institutes of Health, Baltimore, United States) ;
Taura, Jaume (Universitat de Barcelona. Institut de Neurociències) ;
Quiroz, César (National Institutes of Health, Baltimore, United States) ;
Cai, Ning-Sheng (National Institutes of Health, Baltimore, United States) ;
Moreno, Estefanía (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Casadó-Anguera, Verònica (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Kravitz, Alexxai V. (National Institutes of Health, Bethesda, United States) ;
Thompson, Kimberly R. (Circuit Therapeutics, Inc., Menlo Park, United States) ;
Tomasi, Dardo G. (National Institutes of Health, Rockville, United States) ;
Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Lluís, Carme (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Dessauer, Carmen W. (University of Texas Health Science Center at Houston, United States) ;
Volkow, Nora D. (National Institutes of Health, Rockville, United States) ;
Casadó, Vicent (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Ciruela, Francisco (Universitat de Barcelona. Institut de Neurociències) ;
Logothetis, Diomedes E. (Northeastern University, Boston, United States) ;
Zwilling, Daniel (Circuit Therapeutics, Inc, Menlo Park, United States)
The central adenosine system and adenosine receptors play a fundamental role in the modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co-localization of different adenosine and dopamine receptor subtypes in the two populations of striatal efferent neurons, striatonigral and striatopallidal, that give rise to the direct and indirect striatal efferent pathways, respectively. [...]
2018 - 10.3389/fphar.2018.00243
Frontiers in Pharmacology, Vol. 9 (april 2018)
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5.
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17 p, 2.9 MB |
Analysis of Human Dopamine D Receptor Quaternary Structure
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Marsango, Sara (University of Glasgow) ;
Caltabiano, Gianluigi 1978- (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Pou, Chantevy (University of Glasgow) ;
Varela Liste, María José (University of Glasgow) ;
Milligan, Graeme (University of Glasgow)
Background: The dopamine D receptor can form dimers/oligomers, but the molecular basis for this is poorly defined. Results: Molecular modeling, mutagenesis, and analysis of inactive state receptor crystal structures allowed assessment of models of receptor organization. [...]
2015 - 10.1074/jbc.M114.630681
Journal of biological chemistry, Vol. 290 (april 2015) , p. 15146-15162
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6.
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27 p, 5.0 MB |
Cellular distribution of the histamine H3 receptor in the basal ganglia : functional modulation of dopamine and glutamate neurotransmission
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González Sepúlveda, Marta (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Rosell Vilar, Santi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Hoffmann, Hanne Mette (University of Montpellier II) ;
Castillo-Ruiz, Mª del Mar (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Mignon, Virginie (Université Paris Descartes) ;
Moreno Delgado, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Vignes, Michel (University of Montpellier II) ;
Díaz, Jorge (Université Paris Descartes) ;
Sabrià i Pau, Josefa (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ortiz de Pablo, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Histamine H3 receptors (H3R) are widely expressed in the brain where they participate in sleep-wake cycle and cognition among other functions. Despite their high expression in some regions of the basal ganglia, their functional role in this forebrain neural network remains unclear. [...]
2013 - 10.1016/j.baga.2012.12.001
Basal ganglia, Vol. 3 No. 2 (Jul. 2013) , p. 109-121
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7.
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15 p, 1.1 MB |
Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
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González, Sergio (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Moreno Delgado, David (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Moreno, Estefanía (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Pérez-Capote, Kamil (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Mallol, Josefa (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Cortés, Antoni (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Casadó, Vicent (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Lluís, Carme (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ortiz de Pablo, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ferré, Sergi (National Institute on Drug Abuse (Baltimore, Estats Units d'Amèrica)) ;
Canela, Enric I (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
McCormick, Peter J. (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. [...]
2012 - 10.1371/journal.pbio.1001347
PLoS biology, Vol. 10 Issue 6 (June 2012) , p. e1001347
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