Home > Search Results: Spindle assembly checkpoint (SAC)
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6 p, 1.1 MB A role for the spindle assembly checkpoint in the DNA damage response / Palou, Roger (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Palou Marin, Gloria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Garcia Quintana, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress, acting as an anti-cancer barrier in humans. [...]
2016 - 10.1007/s00294-016-0634-y
Current Genetics, Vol. 63, Num. 2 (August 2016) , p. 275-280  
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