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Articles, 1 registres trobats
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12 p, 1.1 MB Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants / Molins, Blanca (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Fuentes-Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau) ; Adan Civera, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Antón, Rosa (Institut d'Investigació Biomèdica Sant Pau) ; Aróstegui, Juan Ignacio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Yagüe, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Dick, Andrew D. (University College London Institute of Ophthalmology) ; Universitat Autònoma de Barcelona
Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the pathophysiological importance of the prototypical acute-phase reactant in the etiology of the disease is unknown, and data regarding the exact role of CRP in ocular inflammation are limited. [...]
2016 - 10.1038/srep22889
Scientific reports, Vol. 6 (03 2016)  

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