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11.
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5 p, 449.3 KB |
Prophylactic Effect of a Therapeutic Vaccine against TB Based on Fragments of Mycobacterium tuberculosis
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Vilaplana, Cristina (Institut Germans Trias i Pujol) ;
Gil, Olga (Institut Germans Trias i Pujol) ;
Cáceres, Neus (Institut Germans Trias i Pujol) ;
Pinto, Sergio (Institut Germans Trias i Pujol) ;
Díaz, Jorge (Institut Germans Trias i Pujol) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol)
The prophylactic capacity of the RUTI® vaccine, based on fragmented cells of Mycobacterium tuberculosis, has been evaluated in respect to aerosol challenge with virulent bacilli. Subcutaneous vaccination significantly reduced viable bacterial counts in both lungs and spleens of C57Bl mice, when challenged 4 weeks after vaccination. [...]
2011 -  10.1371/journal.pone.0020404
PloS one, Vol. 6 (may 2011)
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12.
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8 p, 406.8 KB |
To Achieve an Earlier IFN-γ Response Is Not Sufficient to Control Mycobacterium tuberculosis Infection in Mice
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Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prats, Clara (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear) ;
Marzo, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barril, Carles (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear) ;
Vegué, Marina (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear) ;
Díaz, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls, Joaquim (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear) ;
López, Daniel (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. [...]
2014 - 10.1371/journal.pone.0100830
PloS one, Vol. 9 (june 2014)
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13.
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14.
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12 p, 3.1 MB |
A Beneficial Effect of Low-Dose Aspirin in a Murine Model of Active Tuberculosis
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Kroesen, Vera Marie (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Martínez, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García, Eric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosales, Yaiza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martín-Céspedes, Montse (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
An excessive, non-productive host-immune response is detrimental in active, chronic tuberculosis (TB) disease as it typically leads to tissue damage. Given their anti-inflammatory effect, non-steroidal anti-inflammatory drugs can potentially attenuate excessive inflammation in active TB disease. [...]
2018 - 10.3389/fimmu.2018.00798
Frontiers in immunology, Vol. 9 (april 2018)
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15.
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26 p, 5.0 MB |
A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis
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Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon ;
Coupet, Charles-Antoine (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon) ;
Gouanvic, Marie (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon) ;
Schmitt, Doris (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Ray, Aurélie (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon) ;
Hoffmann, Chantal (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Schultz, Huguette (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Tyagi, Sandeep (Johns Hopkins University, Baltimore) ;
Soni, Heena (Johns Hopkins University, Baltimore) ;
Converse, Paul J. (Johns Hopkins University, Baltimore) ;
Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Kleinpeter, Patricia (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Sansas, Benoît (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Mdluli, Khisimuzi (Global Alliance for Tuberculosis Drug Development, New York) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Nuermberger, Eric (Johns Hopkins University, Baltimore, Maryland) ;
Marchand, Jean-Baptiste (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Silvestre, Nathalie (Boulevard Gonthier d'Andernach, Parc d'innovation, Illkirch-Graffenstaden) ;
Inchauspé, Geneviève (Infectious Diseases department, Centre d'Infectiologie, Bât Domilyon, Lyon)
Despite the existence of the prophylactic Bacille Calmette-Guérin (BCG) vaccine, infection by Mycobacterium tuberculosis (Mtb) remains a major public health issue causing up to 1. 8 million annual deaths worldwide. [...]
2018 - 10.1371/journal.pone.0196815
PloS one, Vol. 13 (may 2018)
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16.
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11 p, 2.5 MB |
High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis
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Billeskov, Rolf (Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen) ;
Lindenstrøm, Thomas (Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen) ;
Woodworth, Joshua (Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen) ;
Vilaplana, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cassidy, Joseph P. (University College Dublin, Belfield) ;
Mortensen, Rasmus (Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen) ;
Agger, Else Marie (Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen) ;
Andersen, Peter (Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen)
Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1. 8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world's population with latent Mtb infection (LTBI), and 5-10% of these people will reactivate and develop active TB. [...]
2018 - 10.3389/fimmu.2017.01973
Frontiers in immunology, Vol. 8 (january 2018)
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17.
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18 p, 7.7 MB |
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
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Moreira-Teixeira, Lúcia (The Francis Crick Institute, London) ;
Stimpson, Philippa J. (The Francis Crick Institute, London) ;
Stavropoulos, Evangelos (The Francis Crick Institute, London) ;
Hadebe, Sabelo (The Francis Crick Institute, London) ;
Chakravarty, Probir (The Francis Crick Institute, London) ;
Ioannou, Marianna (The Francis Crick Institute, London) ;
Aramburu, Iker Valle (The Francis Crick Institute, London) ;
Herbert, Eleanor (The Francis Crick Institute, London) ;
Priestnall, Simon L. (The Francis Crick Institute, London) ;
Suarez-Bonnet, Alejandro (The Francis Crick Institute, London) ;
Sousa, Jeremy (Universidade do Porto. ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Porto) ;
Fonseca, Kaori L. (Instituto Gulbenkian de Ciência (IGC), Oeiras) ;
Wang, Qian (The Francis Crick Institute, London) ;
Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi) ;
Rodríguez-Martínez, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saraiva, Margarida (Universidade do Porto. IBMC - Instituto de Biologia Molecular e Celular) ;
Papayannopoulos, Venizelos (The Francis Crick Institute, London) ;
O'Garra, Anne (Imperial College London)
Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in mouse models of TB. [...]
2020 - 10.1038/s41467-020-19412-6
Nature communications, Vol. 11 (november 2020)
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18.
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25 p, 2.6 MB |
Modelling the dynamics of tuberculosis lesions in a virtual lung : Role of the bronchial tree in endogenous reinfection
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Català, Martí (Universitat Politècnica de Catalunya. Departament de Física) ;
Bechini Bernad, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tenesa, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Andrés, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Moya, Mariano (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls, Joaquim (Universitat Politècnica de Catalunya. Departament de Física) ;
Alonso Muñoz, Sergio (Universitat Politècnica de Catalunya. Departament de Física) ;
López, Daniel (Universitat Politècnica de Catalunya. Departament de Física) ;
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prats, Clara (Universitat Politècnica de Catalunya. Departament de Física)
Tuberculosis (TB) is an infectious disease that still causes more than 1. 5 million deaths annually. The World Health Organization estimates that around 30% of the world's population is latently infected. [...]
2020 - 10.1371/journal.pcbi.1007772
PLoS computational biology, Vol. 16 (may 2020)
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19.
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25 p, 4.1 MB |
Protective Efficacy of Inhaled BCG Vaccination Against Ultra-Low Dose Aerosol M. tuberculosis Challenge in Rhesus Macaques
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White, Andrew D. (National Infection Service (Salisbury, Regne Unit)) ;
Sarfas, Charlotte (National Infection Service (Salisbury, Regne Unit)) ;
Sibley, Laura S. (National Infection Service (Salisbury, Regne Unit)) ;
Gullick, Jennie (National Infection Service (Salisbury, Regne Unit)) ;
Clark, Simon (National Infection Service (Salisbury, Regne Unit)) ;
Rayner, Emma (National Infection Service (Salisbury, Regne Unit)) ;
Gleeson, Fergus (The Churchill Hospital, Headington, UK) ;
Català, Martí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nogueira, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dennis, Mike J. (National Infection Service (Salisbury, Regne Unit)) ;
Williams, Ann (National Infection Service (Salisbury, Regne Unit)) ;
Sharpe, Sally A. (National Infection Service (Salisbury, Regne Unit))
Ten million cases of tuberculosis (TB) were reported in 2018 with a further 1. 5 million deaths attributed to the disease. Improved vaccination strategies are urgently required to tackle the ongoing global TB epidemic. [...]
2020 - 10.3390/pharmaceutics12050394
Pharmaceutics, Vol. 12 (april 2020)
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20.
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14 p, 2.6 MB |
Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium
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Matos, Rita (ICBAS-Instituto de Ciências Biomédicas Abel Salazar, University of Porto) ;
Fonseca, Kaori L. (Programa de Pós-Graduação Ciência para o Desenvolvimento (PGCD), Instituto Gulbenkian de Ciência (IGC)) ;
Mereiter, Stefan (IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto) ;
Maceiras, Ana Raquel (IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto) ;
Gomes, Joana (IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gartner, Fátima (ICBAS-Instituto de Ciências Biomédicas Abel Salazar, University of Porto) ;
Rodrigues, Pedro N. S. (IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto) ;
Reis, Celso A. (FMUP-Faculdade de Medicina da Universidade do Porto) ;
Saraiva, Margarida (IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto) ;
Magalhães, Ana (IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto)
Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown. This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis. [...]
2021 - 10.3390/microorganisms9010099
Microorganisms, Vol. 9 (january 2021)
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