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12 p, 608.0 KB Switching from a ritonavir-boosted protease inhibitor to a dolutegravir-based regimen for maintenance of HIV viral suppression in patients with high cardiovascular risk / Gatell, José Mª (Hospital Clínic i Provincial de Barcelona) ; Assoumou, Lambert (UPMC Univ Paris 06) ; Moyle, Graeme (St Chelsea and Westminster Hospital) ; Waters, Laura (Mortimer Market Center) ; Johnson, Margaret (Royal Free Hospital) ; Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ; Fox, Julie (Guys and St. Thomas Hospital) ; Martinez, Esteban (Hospital Clínic i Provincial de Barcelona) ; Stellbrink, Hans-Jürgen (ICH Study Centrum) ; Guaraldi, Giovanni (University of Modena and Reggio Emilia) ; Masia, Mar (Hospital General Universitario de Elche) ; Gompels, Marl (Southmead Hospital) ; De Wit, Stephane (Université Libre de Bruxelles) ; Florence, Eric (Institute of Tropical Medicine) ; Esser, Stefan (Universitatsklinikum) ; Raffi, François (CHU de Nantes) ; Pozniak, Anton L. (St Chelsea and Westminster Hospital) ; Universitat Autònoma de Barcelona
To compare the efficacy, safety, and impact on lipid fractions of switching from a ritonavir-boosted protease inhibitor (PI/r) to a dolutegravir (DTG) regimen. HIV type 1-infected adults more than 50 years or with a Framingham score more than 10% were eligible if plasma HIV RNA less than 50 copies per ml for at least 24 weeks while on a PI/r regimen. [...]
2017 - 10.1097/QAD.0000000000001675
AIDS, Vol. 31 Núm. 18 (28 2017) , p. 2503-2514  
Registre complet - Creative Commons
2.
7 p, 259.3 KB Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment : Collaborative Cohort Study / May, Margaret T. ; Vehreschild, Jorg-Janne ; Trickey, Adam ; Obel, Niels ; Reiss, Peter ; Bonnet, Fabrice ; Mary-Krause, Murielle ; Samji, Hasina ; Cavassini, Matthias ; Gill, Michael John ; Shepherd, Leah C. ; Crane, Heidi ; D'Arminio Monforte, Antonella ; Burkholder, Greer A. ; Johnson, Margaret M. ; Sobrino-Vegas, Paz ; Domingo, Pere (Domingo Pedrol) ; Zangerle, Robert (Universitat Autònoma de Barcelona. Departament de Medicina) ; Justice, Amy C. ; Sterling, Timothy R. ; Miró, José M. ; Sterne, Jonathan A. C.
The strong association of CD4 count at start of combination therapy with subsequent survival in HIV-infected patients diminished during the first 5 years of treatment. After 5 years, lower baseline CD4 counts were not associated with higher mortality. [...]
2016 - 10.1093/cid/ciw183
Clinical Infectious Diseases, Vol. 62 (march 2016) , p. 1571-1577  
Registre complet - Creative Commons

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