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26 p, 12.8 MB |
Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci
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Lv, Feng-Hua (China Agricultural University. College of Animal Science and Technology) ;
Cao, Yin-Hong (University of Chinese Academy of Sciences . College of Life Sciences) ;
Liu, Guang-Jian (Novogene Bioinformatics Institute) ;
Luo, Ling-Yun (China Agricultural University. College of Animal Science and Technology) ;
Lu, Ran (China Agricultural University. College of Animal Science and Technology) ;
Liu, Ming-Jun (Xinjiang Academy of Animal Science. Animal Biotechnological Research Center) ;
Li, Wen-Rong (Xinjiang Academy of Animal Science. Animal Biotechnological Research Center) ;
Zhou, Ping (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Wang, Xin-Hua (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Shen, Min (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Gao, Lei (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Yang, Jing-Quan (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Yang, Hua (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Yang, Yong-Lin (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Liu, Chang-Bin (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Wan, Peng-Cheng (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Zhang, Yun-Sheng (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Pi, Wen-Hui (Xinjiang Academy of Agricultural and Reclamation Sciences. State Key Laboratory of Sheep Genetic Improvement and Healthy Production) ;
Ren, Yan-Ling (Shandong Binzhou Academy of Animal Science and Veterinary Medicine) ;
Shen, Zhi-Qiang (Shandong Binzhou Academy of Animal Science and Veterinary Medicine) ;
Wang, Feng (Nanjing Agricultural University. Institute of Sheep and Goat Science) ;
Wang, Yu-Tao (Kashi University. College of Life and Geographic Sciences) ;
Li, Jin-Quan (Inner Mongolia Agricultural University. College of Animal Science) ;
Salehian-Dehkordi, Hosein (University of Chinese Academy of Sciences. College of Life Sciences) ;
Hehua, Eer (Ningxia Academy of Agriculture and Forestry Sciences. Grass-Feeding Livestock Engineering Technology Research Center) ;
Liu, Yong-Gang (Yunnan Agricultural University. College of Animal Science and Technology) ;
Chen, Jian-Fei (China Agricultural University. College of Animal Science and Technology) ;
Wang, Jian-Kui (China Agricultural University. College of Animal Science and Technology) ;
Deng, Xue-Mei (China Agricultural University. College of Animal Science and Technology) ;
Esmailizadeh, Ali (Shahid Bahonar University of Kerman. Department of Animal Science) ;
Dehghani-Qanatqestani, Mostafa (Shahid Bahonar University of Kerman. Department of Animal Science) ;
Charati, Hadi (Shahid Bahonar University of Kerman. Department of Animal Science) ;
Nosrati, Maryam (Payame Noor University. Department of Agriculture) ;
Štěpánek, Ondřej (State Veterinary Institute Jihlava. Department of Virology) ;
Rushdi, Hossam E (Cairo University. Department of Animal Production) ;
Olsaker, Ingrid (Norwegian University of Life Sciences. Department of Preclinical Sciences and Pathology) ;
Curik, Ino (University of Zagreb. Department of Animal Science) ;
Gorkhali, Neena A (Nepal Agriculture Research Council. Animal Breeding Division, National Animal Science Institute) ;
Paiva, Samuel R (Embrapa Recursos Genéticos e Biotecnologia) ;
Caetano, Alexandre R (Embrapa Recursos Genéticos e Biotecnologia) ;
Ciani, Elena (Università degli Studi di Bari. Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica) ;
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Weimann, Christina (Justus-Liebig-University Giessen. Department of Animal Breeding and Genetics) ;
Erhardt, Georg (Justus-Liebig-University Giessen. Department of Animal Breeding and Genetics) ;
Amane, Agraw (International Livestock Research Institute) ;
Mwacharo, Joram M (The Roslin Institute Building) ;
Han, Jian-Lin (International Livestock Research Institute (Nairobi, Kènia)) ;
Hanotte, Olivier (University of Nottingham. School of Life Sciences) ;
Periasamy, Kathiravan (International Atomic Energy Agency. Animal Production and Health Laboratory) ;
Johansson, Anna M (Swedish University of Agricultural Sciences. Department of Animal Breeding and Genetics) ;
Hallsson, Jón H (Agricultural University of Iceland. Faculty of Natural Resources and Environmental Sciences) ;
Kantanen, Juha (Natural Resources Institute Finland. Production Systems) ;
Coltman, David W (University of Alberta. Department of Biological Sciences) ;
Bruford, Michael W (Cardiff University. Sustainable Places Research Institute) ;
Lenstra, Johannes A (Utrecht University. Faculty of Veterinary Medicine) ;
Li, Meng-Hua (China Agricultural University. College of Animal Science and Technology)
Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16. [...]
2021 -  10.1093/molbev/msab353
Molecular biology and evolution, Vol. 39 (december 2021)
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11 p, 1.8 MB |
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
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Klein, Alison P. (Johns Hopkins School of Medicine, Baltimore, USA) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute, Boston, USA) ;
Risch, Harvey A. (Yale School of Public Health, New Haven, USA) ;
Stolzenberg-Solomon, Rachael Z. (National Institutes of Health, Bethesda, USA) ;
Mocci, Evelina (Johns Hopkins School of Medicine, Baltimore, USA) ;
Zhang, Mingfeng (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Canzian, Federico (Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Childs, Erica J. (Johns Hopkins School of Medicine, Baltimore, USA) ;
Hoskins, Jason W. (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Jermusyk, Ashley (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Zhong, Jun (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Chen, Fei (Johns Hopkins School of Medicine, Baltimore, USA) ;
Albanes, Demetrius (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Andreotti, Gabriella (National Institutes of Health, Bethesda, USA) ;
Arslan, Alan A. (New York University School of Medicine, New York, USA) ;
Babic, Ana (Dana-Farber Cancer Institute, Boston, USA) ;
Bamlet, William R. (Mayo Clinic College of Medicine, Rochester, USA) ;
Beane-Freeman, Laura (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Berndt, Sonja (National Institutes of Health, Bethesda, USA) ;
Blackford, Amanda (Johns Hopkins School of Medicine, Baltimore, USA) ;
Borges, Michael (Johns Hopkins School of Medicine, Baltimore, USA) ;
Borgida, Ayelet (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, M5G 1×5, Canada.) ;
Bracci, Paige M. (University of California, San Francisco, USA) ;
Brais, Lauren (Dana-Farber Cancer Institute, Boston, USA) ;
Brennan, Paul (International Agency for Research on Cancer (IARC), Lyon, France) ;
Brenner, Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands) ;
Buring, Julie (Division of Preventive Medicine, Brigham and Women's Hospital, Boston) ;
Campa, Daniele (University of Pisa) ;
Capurso, Gabriele (University of Rome) ;
Cavestro, Giulia Martina (Vita-Salute San Raffaele University, Milan) ;
Chaffee, Kari G (Mayo Clinic College of Medicine, Rochester, USA) ;
Chung, Charles C. (National Institutes of Health, Bethesda, USA) ;
Cleary, Sean (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada) ;
Cotterchio, Michelle (University of Toronto.) ;
Dijk, Frederike (University of Amsterdam. Department of Pathology, Academic Medical Center) ;
Duell, Eric J. (Institut d'Investigació Biomèdica de Bellvitge) ;
Foretova, Lenka (Masaryk Memorial Cancer Institute. Department of Cancer Epidemiology and Genetics, Brno, Czech Republic.) ;
Fuchs, Charles (Yale Cancer Center, New Haven, USA) ;
Funel, Niccola (University of Pisa.) ;
Gallinger, Steven (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada) ;
M. Gaziano, J. Michael (Boston VA Healthcare System) ;
Gazouli, Maria (National and Kapodistrian University of Athens) ;
Giles, Graham G. (Monash University. Department of Epidemiology and Preventive Medicine, Melbourne, Australia) ;
Giovannucci, Edward (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Goggins, Michael (Johns Hopkins School of Medicine. Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Baltimore) ;
Goodman, Gary E. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences, Seattle, USA) ;
Goodman, Phyllis J. (Fred Hutchinson Cancer Research Center. SWOG Statistical Center, Seattle, USA) ;
Hackert, Thilo (University Hospital Heidelberg, Germany) ;
Haiman, Christopher A (University of Southern California, USA) ;
Hartge, Patricia (National Institutes of Health, Bethesda, USA) ;
Hasan, Manal (University of Texas MD Anderson Cancer Center, USA) ;
Hegyi, Peter (University of Szeged, Szeged, Hungary) ;
Helzlsouer, Kathy J. (National Institutes of Health, Bethesda, USA) ;
Herman, Joseph (Johns Hopkins School of Medicine. Baltimore, USA) ;
Holcatova, Ivana (Charles University, Prague, Czech Republic) ;
Holly, Elizabeth A. (University of California, San Francisco) ;
Hoover, Robert (National Institutes of Health, Bethesda, USA) ;
Hung, Rayjean J. (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada) ;
Jacobs, Eric J. (American Cancer Society. Epidemiology Research Program, Atlanta) ;
Jamroziak, Krzysztof (Institute of Hematology and Transfusion Medicine, Warsaw, Poland) ;
Janout, Vladimir (Faculty of Medicine, University of Olomouc, Czech Republic) ;
Kaaks, Rudolf (German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Khaw, Kay-Tee (University of Cambridge) ;
Klein, Eric A. (Cleveland Clinic) ;
Kogevinas, M (Hospital del Mar (Barcelona, Catalunya)) ;
Kooperberg, Charles (Fred Hutchinson Cancer Research Center, Seattle) ;
Kulke, Matthew H. (Dana-Farber Cancer Institute, Boston) ;
Kupcinskas, Juozas (Lithuanian University of Health Sciences, Kaunas, Lithuania) ;
Kurtz, Robert J. (Memorial Sloan Kettering Cancer Center, New York, USA) ;
Laheru, Daniel (Johns Hopkins School of Medicine, Baltimore, USA) ;
Landi, Stefano (University of Pisa) ;
Lawlor, Rita T. (University and Hospital Trust of Verona) ;
Lee, I.-Min (Harvard School of Public Health, Boston) ;
LeMarchand, Loic (University of Hawaii Cancer Center, Honolulu, USA) ;
Lu, Lingeng (Yale School of Public Health, New Haven, USA) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer, Madrid) ;
Mambrini, Andrea (Oncology Department, ASL1 Massa Carrara, Italy) ;
Mannisto, Satu (National Institute for Health and Welfare, Helsinki, Finland) ;
Milne, Roger L. (The University of Melbourne, Australia) ;
Mohelníková-Duchoňová, Beatrice (Palacky University Olomouc and University Hospital, Czech Republic) ;
Neale, Rachel E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Neoptolemos, John P. (University of Heidelburg, Heidelberg, Germany) ;
Oberg, Ann L. (Mayo Clinic College of Medicine, Rochester, USA) ;
Olson, Sara H. (Memorial Sloan Kettering Cancer Center, New York, USA) ;
Orlow, Irene (Memorial Sloan Kettering Cancer Center, New York, USA) ;
Pasquali, Claudio (University of Padua, Italy) ;
Patel, Alpa V. (American Cancer Society, Atlanta) ;
Peters, Ulrike (Fred Hutchinson Cancer Research Center, Seattle) ;
Pezzilli, Raffaele (Sant'Orsola-Malpighi Hospital, Bologna, Italy) ;
Porta, Miquel 1957- (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Real, Francisco X. (Universitat Pompeu Fabra) ;
Rothman, Nathaniel (National Institutes of Health, Bethesda, USA) ;
Scelo, Ghislaine (International Agency for Research on Cancer (IARC), Lyon, France) ;
Sesso, Howard D. (Harvard T.H. Chan School of Public Health. Department of Epidemiology) ;
Severi, Gianluca (Université Paris-Saclay, France) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine, Nashville, USA) ;
Silverman, Debra (National Institutes of Health, Bethesda, USA) ;
Smith, Jill P. (Georgetown University, Washington, USA) ;
Soucek, Pavel (Charles University, Pilsen, Czech Republic.) ;
Sund, Malin (Umeå University, Sweden) ;
Talar-Wojnarowska, Renata (Medical University of Łodz, Poland) ;
Tavano, Francesca (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS), Italy) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center, Seattle) ;
Tobias, Geoffrey S. (National Institutes of Health, Bethesda, USA) ;
Van Den Eeden, Stephen K. (Kaiser Permanente Northern California, USA) ;
Vashist, Yogesh (University Hamburg-Eppendorf, Germany) ;
Visvanathan, Kala (Johns Hopkins Bloomberg School of Public Health, Baltimore, USA) ;
Vodicka, Pavel (Academy of Sciences of the Czech Republic, Prague, Czech Republic) ;
Wactawski-Wende, Jean (University at Buffalo, USA) ;
Wang, Zhaoming (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ;
Wentzensen, Nicolas (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
White, Emily (University of Washington, USA) ;
Yu, Herbert (University of Hawaii Cancer Center, USA) ;
Yu, Kai (National Institutes of Health, Bethesda, USA) ;
Zeleniuch-Jacquotte, Anne (New York University School of Medicine, USA) ;
Zheng, Wei (Vanderbilt University School of Medicine, Nashville, USA) ;
Kraft, Peter (Harvard School of Public Health, USA) ;
Li, Donghui (University of Texas MD Anderson Cancer Center, USA) ;
Chanock, Stephen (National Institutes of Health, Bethesda, USA) ;
Obazee, Ofure (German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine, Rochester, USA) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica))
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). [...]
2018 - 10.1038/s41467-018-02942-5
Nature communications, Vol. 9 (february 2018)
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