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1.
11 p, 6.7 MB Gene Expression Analysis of the Bone Marrow Microenvironment Reveals Distinct Immunotypes in Smoldering Multiple Myeloma Associated to Progression to Symptomatic Disease / Isola, Ignacio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Brasó-Maristany, Fara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Moreno, David F. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Mena, Mari Pau (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Oliver-Caldés, Aina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Paré Brunet, Laia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rodríguez Lobato, Luis Gerardo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Martín-Antonio, B (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Cibeira, María Teresa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Prat, Aleix (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lozano, Ester (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Fernández de Larrea, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: We previously reported algorithms based on clinical parameters and plasma cell characteristics to identify patients with smoldering multiple myeloma (SMM) with higher risk of progressing who could benefit from early treatment. [...]
2021 - 10.3389/fimmu.2021.792609
Frontiers in immunology, Vol. 12 (22 2021) , p. 792609  
2.
27 p, 3.4 MB T cells isolated from G-CSF-treated multiple myeloma patients are suitable for the generation of BCMA-directed CAR-T cells / Battram, Anthony M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Oliver-Caldés, Aina (Hospital Clínic i Provincial de Barcelona) ; Suárez Lledó, Maria (Hospital Clínic i Provincial de Barcelona) ; Lozano, Miquel (Hospital Clínic i Provincial de Barcelona) ; Bosch i Crespo, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Martínez Cibrián, Núria (Hospital Clínic i Provincial de Barcelona) ; Cid, Joan (Hospital Clínic i Provincial de Barcelona) ; Moreno, David F. (Hospital Clínic i Provincial de Barcelona) ; Rodríguez Lobato, Luis Gerardo (Hospital Clínic i Provincial de Barcelona) ; Urbano Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández de Larrea, Carlos (Universitat de Barcelona)
Autologous cell immunotherapy using B cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cells is an effective novel treatment for multiple myeloma (MM). This therapy has only been used for relapsed and refractory patients, at which stage the endogenous T cells used to produce the CAR-T cells are affected by the immunosuppressive nature of advanced MM and/or side effects of previous therapies. [...]
2022 - 10.1016/j.omtm.2022.06.010
Molecular Therapy. Methods & Clinical Development, Vol. 26 (august 2022) , p. 207-223  

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