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Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model / Montero, María M. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Domene-Ochoa, Sandra (Institut Hospital del Mar d'Investigacions Mèdiques) ; López-Causapé, Carla (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Luque, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ; Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques) ; Campillo, Núria (Hospital del Mar (Barcelona, Catalunya)) ; Padilla León, Eduardo (Laboratori de Referència de Catalunya (El Prat de Llobregat, Catalunya)) ; Prim, Núria (Laboratori de Referència de Catalunya (El Prat de Llobregat, Catalunya)) ; Ferrer-Alapont, Lorena (Institut Hospital del Mar d'Investigacions Mèdiques) ; Angulo-Brunet, Ariadna (Universitat Oberta de Catalunya) ; Grau, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques) ; Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona
Ceftolozane/tazobactam (C/T) has emerged as a potential agent for the treatment of extensively drug-resistant (XDR) Pseudomonas aeruginosa infections. As it is a time-dependent antimicrobial, prolonged infusion may help achieve pharmacokinetic/pharmacodynamic (PK/PD) targets. [...]
2021 - DOI (Digital Object Identifier)

10.1038/s41598-021-01784-4
Scientific reports, Vol. 11 (november 2021)

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