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15 p, 5.1 MB Slow progression of pediatric HIV associates with early CD8 + T cell PD-1 expression and a stem-like phenotype / Vieira, Vinicius (Department of Paediatrics, University of Oxford) ; Lim, Nicholas (Department of Paediatrics, University of Oxford) ; Singh, Alveera (Africa Health Research Institute) ; Leitman, Ellen (Department of Paediatrics, University of Oxford) ; Dsouza, Reena (Department of Paediatrics, University of Oxford) ; Adland, Emily (Department of Paediatrics, University of Oxford) ; Muenchhoff, Maximilian (German Center for Infection Research) ; Roider, Julia (Department of Infectious Diseases, Ludwig-Maximilians-University) ; Marin Lopez, Miguel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Carabelli, Julieta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Giandhari, Jennifer (KwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) ; Groll, Andreas (Department of Statistics, TU Dortmund University) ; Jooste, Pieter (Department of Paediatrics, Kimberley Hospital) ; Prado, Julia G. (Institut Germans Trias i Pujol) ; Thobakgale, Christina (University of KwaZulu-Natal) ; Dong, Krista (Ragon Institute of MGH, MIT and Harvard (Estats Units d'Amèrica)) ; Kiepiela, Photini (Wits Health Consortium, Johannesburg) ; Prendergast, Andrew J. (Zvitambo Institute for Maternal and Child Health Research) ; Tudor-Williams, Gareth (Imperial College London. Centre for Paediatrics and Child Health) ; Frater, John (Oxford NIHR Biomedical Research Centre) ; Walker, Bruce D. (Ragon Institute of MGH, MIT and Harvard) ; Ndung'u, Thumbi (University College London. Division of Infection and Immunity) ; Ramsuran, Veron (Centre for the AIDS Programme of Research in South Africa) ; Leslie, Alasdair (School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal) ; Kløverpris, Henrik N. (Department of Immunology and Microbiology, University of Copenhagen) ; Goulder, Philip (Doris Duke Medical Research Institute, University of KwaZulu-Natal) ; Universitat Autònoma de Barcelona
HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive children. Previous studies indicate that ART-naive pediatric slow progressors (PSPs) adopt immune evasion strategies similar to those described in natural hosts of SIV. [...]
202 - 10.1172/jci.insight.156049
JCI Insight, Vol. 8 (february 2023)  
Detailed record - Creative Commons

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