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10 p, 1.6 MB The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes / Nieto-Fontarigo, Juan José (Universidade de Santiago de Compostela) ; Salgado, F. J. (Universidade de Santiago de Compostela) ; San-José, M. E. (Complejo Hospitalario Universitario de Santiago de Compostela) ; Cruz Carmona, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Casas-Fernández, A. (Complejo Hospitalario Universitario de Santiago de Compostela) ; Gómez-Conde, M. J. (Complejo Hospitalario Universitario de Santiago de Compostela) ; Valdés-Cuadrado, L. (Complejo Hospitalario Universitario de Santiago de Compostela) ; García-González, M. Á. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Arias, Pilar (Universidade de Santiago de Compostela) ; Nogueira, Montserrat (Universidade de Santiago de Compostela) ; González-Barcala, Francisco-Javier (Complejo Hospitalario Universitario de Santiago de Compostela) ; Universitat Autònoma de Barcelona
LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH-differentiation, counteracting the TH-driven asthma. Therefore, CD14 modulation could alter the TH-differentiation and should be taken into account when studying asthma. [...]
2018 - 10.1038/s41598-018-20483-1
Scientific reports, Vol. 8 (march 2018)  
Detailed record - Creative Commons

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