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4 p, 55.5 KB |
Infeccions respiratòries, usos adequats d'antibiòtics i noves eines diagnòstiques i terapèutiques
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Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina, dir. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Actualment, les malalties respiratòries que inclouen infeccions agudes, com pneumònies i bronquitis i també infeccions cròniques, en pacients amb malalties de base com la malaltia pulmonar obstructiva crònica o l'asma, representen un dels problemes més greus de la salut pública per la seva alta mortalitat i morbiditat. [...]
Actualmente, las enfermedades respiratorias que incluyen infecciones agudas, como neumonías y bronquitis y también infecciones crónicas, en pacientes con enfermedades de base como la enfermedad pulmonar obstructiva crónica o el asma, representan uno de los problemas más graves de la salud pública por su alta mortalidad y morbilidad. [...]
2019
UAB divulga, Maig 2019, p. 1-4
2 documentos
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17.
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7 p, 1.1 MB |
PyroTyping, a novel pyrosequencing-based assay for Mycobacterium tuberculosis genotyping
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Molina-Moya, Barbara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Sierra, N. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, S. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Haba, L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Samper, S. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Ruiz Manzano, J.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arnold, C. (Genomic Services and Development Unit, Public Health England) ;
Domínguez, J.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
We developed a novel method, PyroTyping, for discrimination of Mycobacterium tuberculosis isolates combining pyrosequencing and IS6110 polymorphism. A total of 100 isolates were analysed with IS6110-restriction fragment length polymorphism (RFLP), spoligotyping, mycobacterial interspersed repetitive units - variable number tandem repeats (MIRU-VNTR), and PyroTyping. [...]
2017 -  10.1038/s41598-017-06760-5
Scientific reports, Vol. 7 Núm. 6777 (july 2017) , p. 1-7
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18.
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14 p, 1.3 MB |
Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections
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Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pagan Maldonado, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hidalgo, Jessica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molinos Abós, Sònia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez Villanueva, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jenkins, Andrew Toby A. (Department of Chemistry, University of Bath) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Objective. Characterization of Staphylococcus aureus clinical isolates derived from lower respiratory tract infections (LRTIs), and correlation between the functionality of the accessory gene regulator (Agr) and genotypic and phenotypic characteristics, clinical variables and clinical outcome. [...]
2017 - 10.1371/journal.pone.0175552
PloS one, Vol. 12 Núm. 4 (2017) , p. 1-14
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19.
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13 p, 2.4 MB |
Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
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Martínez, Isidoro (Centro Nacional de Microbiología (Espanya)) ;
Oliveros, Juan C. (Centro Nacional de Biotecnologia) ;
Cuesta, Isabel (Centro Nacional de Microbiología (Espanya)) ;
de la Barrera, Jorge (Centro Nacional de Microbiología (Espanya)) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casals, Cristina (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
de Lorenzo, Alba (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
García, Ernesto (Centro de Investigaciones Biológicas (Madrid)) ;
García Fojeda, Belén (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
Garmendia, Junkal (Universidad Pública de Navarra. Instituto de Agrobiotecnología) ;
González Nicolau, Mar (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Menéndez, Margarita (Instituto de Química Física "Rocasolano") ;
Moranta, D. (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Nieto, Amelia (Centro Nacional de Biotecnologia) ;
Ortín, Juan (Centro Nacional de Biotecnologia) ;
Pérez González, Alicia (Centro Nacional de Biotecnologia) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramos Sevillano, Elisa (Centro de Investigaciones Biológicas (Madrid)) ;
Regueiro, Verónica (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Rodriguez Frandsen, Ariel (Centro Nacional de Biotecnologia) ;
Solís, Dolores (Instituto de Química Física "Rocasolano") ;
Yuste, José (Centro de Investigaciones Biológicas (Madrid)) ;
Bengoechea, José A. (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Melero, José A. (Centro Nacional de Microbiología (Espanya)) ;
Universitat Autònoma de Barcelona
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. [...]
2017 - 10.3389/fmicb.2017.00276
Frontiers in microbiology, Vol. 8 (2017) , p. 1-13
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20.
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15 p, 1.2 MB |
Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line
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Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano, Victoria (Institut d'Investigació Sanitària de Palma) ;
Moranta, D. (Institut d'Investigació Sanitària de Palma) ;
Regueiro, Verónica (Institut d'Investigació Sanitària de Palma) ;
Domínguez Villanueva, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González-Nicolau, M. (Institut d'Investigació Sanitària de Palma) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bengoechea, J. A. (Centre for Experimental Medicine, Queen's University Belfast) ;
Universitat Autònoma de Barcelona
Objective : Staphylococcus aureus is a particularly difficult pathogen to eradicate from the respiratory tract. Previous studies have highlighted the intracellular capacity of S. aureus in several phagocytic and non-phagocytic cells. [...]
2017 - 10.1080/21505594.2017.1361089
Virulence, Vol. 8 (september 2017) , p. 1761-1775
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10 p, 345.6 KB |
Prognostic assessment in COPD without lung function : the B-AE-D indices
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Boeck, Lucas (University Hospital Basel (Basilea, Suïssa)) ;
Soriano, Joan B.. (Instituto de Investigación Hospital Universitario de la Princesa) ;
Brusse-Keizer, Marjolein (Medical School Twente, Medisch Spectrum Twente, Enschede, The Netherlands) ;
Blasi, Francesco (Dept of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy) ;
Kostikas, Konstantinos (University of Thessaly Medical School, Larissa, Greece) ;
Boersma, Wim (Dept of Pneumology, Medisch Centrum, Alkmaar, The Netherlands) ;
Milenkovic, Branislava (Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Belgrade, Serbia) ;
Louis, Renaud (Dept of Pneumology, University of Liege, Liege, Belgium) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Djamin, Remco (Dept of Pneumology, Amphia Hospital, Breda, The Netherlands) ;
Aerts, Joachim (Dept of Pneumology, Amphia Hospital, Breda, The Netherlands) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Rohde, Gernot (Dept of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands) ;
Welte, Tobias (Dept of Pneumology, Medizinische Hochschule, Hannover, Germany) ;
Martinez-Camblor, Pablo (Universidad Autónoma de Chile) ;
Rakic, Janko (University Hospital Basel (Basilea, Suïssa)) ;
Scherr, Andreas (University Hospital Basel (Basilea, Suïssa)) ;
Koller, Michael (University Hospital Basel (Basilea, Suïssa)) ;
van der Palen, Job (Medical School Twente, Medisch Spectrum Twente, Enschede, The Netherlands) ;
Marin, Jose M. (Hospital Universitario Miguel Servet (Saragossa)) ;
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Almagro, Pere (Mútua Terrassa) ;
Casanova, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Esteban, Cristobal (Hospital de Galdakao (Usansolo, Biscaia)) ;
Soler-Cataluña, Juan J. (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
De Torres, Juan Pablo (Clínica Universidad de Navarra) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Celli, Bartolomé R. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Tamm, Michael (University Hospital Basel (Basilea, Suïssa)) ;
Stolz, Daiana (University Hospital Basel (Basilea, Suïssa)) ;
Universitat Autònoma de Barcelona
Several composite markers have been proposed for risk assessment in chronic obstructive pulmonary disease (COPD). However, choice of parameters and score complexity restrict clinical applicability. Our aim was to provide and validate a simplified COPD risk index independent of lung function. [...]
2016 - 10.1183/13993003.01485-2015
European respiratory journal, Vol. 47 (april 2016) , p. 1635-1644
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13 p, 336.9 KB |
Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease
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Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Andreo García, Felipe (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lores, Luis (Hospital de Sant Boi, Sant Boi de Llobregat) ;
Ruiz Manzano, J.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The identification of biological markers in order to assess different aspects of COPD is an area of growing interest. The objective of this study was to investigate whether levels of procalcitonin (PCT), C-reactive protein (CRP), and neopterin in COPD patients could be useful in identifying the etiological origin of the exacerbation and assessing its prognosis. [...]
2011 - 10.2147/COPD.S16070
International journal of COPD, Vol. 6 (february 2011) , p. 157-169
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23.
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227 p, 26.7 MB |
Usefulness of molecular methods for detecting drug resistance and genotyping in mycobacterium tuberculosis
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Molina-Moya, Barbara ;
Domínguez Benítez, José Antonio, dir. ;
Prat i Aymerich, Cristina, dir. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lacoma, Alicia, dir. ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
La tuberculosis (TB) es una de las principales enfermedades infecciosas a nivel mundial, y la aparición y propagación de cepas de Mycobacterium tuberculosis, el agente causante, resistentes a distintos fármacos es una amenaza para la salud pública. [...]
Tuberculosis (TB) is one of the major infectious diseases worldwide, and the emergence and spread of drug resistant strains of Mycobacterium tuberculosis, the causative agent, is a public health threat. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2016
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24.
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262 p, 2.4 MB |
Utilitat de la determinació sistèmica de nous biomarcadors en el maneig de les infeccions respiratòries
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Lacoma, Alicia ;
Prat i Aymerich, Cristina, dir. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Domínguez Benítez, José Antonio, dir. ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Malgrat la disponibilitat de tècniques diagnòstiques més ràpides i acurades i de tractaments antibiòtics d'ampli espectre, les infeccions del tracte respiratori inferior continuen sent un problema important per la salut pública mundial. [...]
Despite the development of new diagnostic methods and the availability of broad spectrum antibiotics, lower respiratory tract infections (LRTI) still represent an important worldwide health problem. Specifically for the management of community acquired pneumonia (CAP), an early diagnosis and severity assessment are of major importance, because both guide therapeutical decisions about appropriate treatment, as well as need of hospital admission. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2011
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