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8 p, 257.6 KB |
Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen
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Prat, A. (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Parker, J. S. (University of North Carolina. Lineberger Comprehensive Cancer Center) ;
Fan, C. (LUniversity of North Carolina. Lineberger Comprehensive Cancer Center) ;
Cheang, M. C. U. (University of North Carolina. Lineberger Comprehensive Cancer Center) ;
Miller, L. D. (Wake Forest School of Medicine. Department of Cancer Biology) ;
Bergh, Jonas (Manchester University. Department of Medical Oncology) ;
Chia, S. K. L. (British Columbia Cancer Agency) ;
Bernard, P. S. (University of Utah Health Sciences Center. Department of Pathology) ;
Nielsen, T. O. (University of British Columbia. Department of Pathology) ;
Ellis, M. J. (Siteman Cancer Center at Washington University. Department of Medicine) ;
Carey, L. A. (University of North Carolina. Deparment of Medicine) ;
Perou, Charles M. (University of North Carolina. Pathology & Laboratory Medicine)
ER-positive (ER+) breast cancer includes all of the intrinsic molecular subtypes, although the luminal A and B subtypes predominate. In this study, we evaluated the ability of six clinically relevant genomic signatures to predict relapse in patients with ER+ tumors treated with adjuvant tamoxifen only. [...]
2012 -  10.1093/annonc/mds080
Annals of oncology, Vol. 23 Núm. 11 (november 2012) , p. 2866-2873
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12 p, 3.2 MB |
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type
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Karnezis, Anthony N. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Wang, Yemin (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Ramos, Pilar (Translational Genomics Research Institute) ;
Hendricks, William P. D. (Translational Genomics Research Institute) ;
Oliva, Esther (Massachusetts General Hospital (Boston)) ;
D'Angelo, Emanuela (Institut d'Investigació Biomèdica Sant Pau) ;
Prat, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Nucci, Marisa R. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Nielsen, Torsten O. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Chow, Christine (University of British Columbia. Genetic Pathology Evaluation Centre) ;
Leung, Samuel (University of British Columbia. Genetic Pathology Evaluation Centre) ;
Kommoss, Friedrich (Synlab MVZ Pathologie) ;
Kommoss, Stefan (University Hospital of Tübingen (Alemanya)) ;
Silva, Annacarolina (Harvard Medical School. The James Homer Wright Pathology Laboratories) ;
Ronnett, Brigitte M. (The Johns Hopkins Hospital. Department of Pathology) ;
Rabban, Joseph T. (University of California San Francisco. Department of Anatomic Pathology) ;
Bowtell, David D. (Peter MacCallum Cancer Centre) ;
Weissman, Bernard E. (University of North Carolina. Department of Pathology and Laboratory Medicine) ;
Trent, Jeffrey M. (Translational Genomics Research Institute) ;
Gilks, C. Blake (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Huntsman, David G. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Universitat Autònoma de Barcelona
Small cell carcinoma of the ovary, hypercalcaemic type () is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of harbour inactivating mutations in the chromatin remodelling gene with concomitant loss of its encoded protein (), one of two mutually exclusive of the / chromatin remodelling complex. [...]
2015 - 10.1002/path.4633
The Journal of Pathology, Vol. 238, Issue 3 (december 2015) , p. 389-400
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26 p, 578.2 KB |
Increased sensitivity to climate change in disturbed ecosystems
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Kröel-Dulay, György (Hungarian Academy of Sciences. Institute of Ecology and Botany) ;
Ransijn, Johannes (Københavns Universitet. Institut for Geovidenskab og Naturforvaltning) ;
Schmidt, Inger K. (Københavns Universitet. Institut for Geovidenskab og Naturforvaltning) ;
Beier, Claus (Norsk institutt for vannforskning) ;
De Angelis, Paolo (Università degli studi della Tuscia. Dipartimento per l'Innovazione nei sistemi Biologici, Agroalimentari e Forestali) ;
de Dato, Giovanbattista (Università degli studi della Tuscia. Dipartimento per l'Innovazione nei sistemi Biologici, Agroalimentari e Forestali) ;
Dukes, Jeffrey S. (Purdue University. Department of Forestry and Natural Resources) ;
Emmett, Bridget A. (Centre for Ecology and Hydrology-Bangor) ;
Estiarte, Marc (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Garadnai, János (Hungarian Academy of Sciences. Institute of Ecology and Botany) ;
Kongstad, Jane (Københavns Universitet. Institut for Geovidenskab og Naturforvaltning) ;
Kovàcs-Láng, Edit (Hungarian Academy of Sciences. Institute of Ecology and Botany) ;
Larsen, Klaus Steenberg (Københavns Universitet. Institut for Geovidenskab og Naturforvaltning) ;
Liberati, Dario (Università degli studi della Tuscia. Dipartimento per l'Innovazione nei sistemi Biologici, Agroalimentari e Forestali) ;
Ogaya Inurrigarro, Romà (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Riis-Nielsen, Torben (Københavns Universitet. Institut for Geovidenskab og Naturforvaltning) ;
Smith, Andrew (Bangor University. School of the Environment and Natural Resources) ;
Sowerby, Alwyn (Centre for Ecology & Hydrology, Oxford) ;
Tietema, Albert (Universiteit van Amsterdam. Institute for Biodiversity and Ecosystem Dynamics) ;
Peñuelas, Josep (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Human domination of the biosphere includes changes to disturbance regimes, which push many ecosystems towards early-successional states. Ecological theory predicts that early-successional ecosystems are more sensitive to perturbations than mature systems, but little evidence supports this relationship for the perturbation of climate change. [...]
2015 - 10.1038/ncomms7682
Nature communications, March 2015
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12 p, 915.6 KB |
PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers
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Bastien, Roy R. L. (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Rodríguez-Lescure, Álvaro (Hospital General Universitario de Elche) ;
Ebbert, Mark T. W. (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Prat, Aleix (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Munárriz, Blanca (Hospital Universitari i Politècnic La Fe (València)) ;
Rowe, Leslie (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Miller, Patricia (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Ruiz Borrego, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Anderson, Daniel (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Lyons, Bradley (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Álvarez López, Isabel (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Dowell, Tracy (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Wall, David (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Seguí, Miguel Ángel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Barley, Lee (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Boucher, Kenneth M. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Alba, Emilio (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Pappas, Lisa (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Davis, Carole A. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Aranda, Ignacio (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Fauron, Christiane (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Stijleman, Inge J. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Palacios, José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Antón, Antonio (Hospital Universitario Miguel Servet (Saragossa)) ;
Carrasco, Eva (GEICAM. Spanish Breast Cancer Research Group (Madrid)) ;
Caballero, Rosalía (GEICAM. Spanish Breast Cancer Research Group (Madrid)) ;
Ellis, Matthew J. (Washington University. Department of Oncology (St. Louis, Estats Units d'Amèrica)) ;
Nielsen, Torsten O. (University of British Columbia. Department of Anatomical Pathology (Vancouver, Canadà)) ;
Perou, Charles M. (University of North Carolina at Chapel Hill. Lineberger Comprehensive Cancer Center (Chapel Hill, Estats Units d'Amèrica)) ;
Astill, Mark (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Bernard, Philip S. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Martín Jiménez, Miguel (Hospital General Universitario Gregorio Marañón)
Background: Many methodologies have been used in research to identify the "intrinsic" subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched (HER2-E) and Basal-like. The PAM50 gene set is often used for gene expression-based subtyping; however, surrogate subtyping using panels of immunohistochemical (IHC) markers are still widely used clinically. [...]
2012 - 10.1186/1755-8794-5-44
BMC medical genomics, Vol. 15, N. 44 (October 2012) , p. 1-9
4 documentos
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19 p, 437.9 KB |
Response of plant species richness and primary productivity in shrublands along a north-south gradient in Europe to seven years of experimental warming and drought: reductions in primary productivity in the heat and drought year of 2003
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Peñuelas, Josep (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Prieto, Patricia (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Beier, Claus (RISØ National Laboratory) ;
Cessaraccio, Carla (National Research Council of Italy. Institute of Biometeorology) ;
De Angelis, Paolo (University of Tuscia. Department of Forest Environment and Resources) ;
de Dato, Giovanbattista (University of Tuscia. Department of Forest Environment and Resources) ;
Emmett, Bridget A. (Centre for Ecology and Hydrology-Bangor) ;
Estiarte, Marc (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Garadnai, János (Hungarian Academy of Sciences. Institute of Ecology and Botany) ;
Gorissen, Antonie (Plant Research International) ;
Lang, Edit Kovacs (Hungarian Academy of Sciences. Institute of Ecology and Botany) ;
Kröel-Dulay, György (Hungarian Academy of Sciences. Institute of Ecology and Botany) ;
Llorens, Laura (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Pellizaro, Grazia (National Research Council of Italy. Institute of Biometeorology) ;
Riis-Nielsen, Torben (University of Copenhagen. University of Copenhagen) ;
Schmidt, Inger K. (University of Copenhagen. University of Copenhagen) ;
Sirca, Constantino (Univeristy of Sassari. Department of Economics and Tree Crops) ;
Sowerby, Alwyn (Centre for Ecology and Hydrology-Bangor) ;
Spano, Donatella (Univeristy of Sassari. Department of Economics and Tree Crops) ;
Tietema, Albert (Universiteit van Amsterdam. Center for Geo-ecological Research)
We used a nonintrusive field experiment carried out at six sites - Wales (UK), Denmark (DK), the Netherlands (NL), Hungary (HU), Sardinia (Italy - IT), and Catalonia (Spain - SP) - along a climatic and latitudinal gradient to examine the response of plant species richness and primary productivity to warming and drought in shrubland ecosystems. [...]
2007 - 10.1111/j.1365-2486.2007.01464.x
Global change biology, Vol. 13, Núm. 12 (Desembre 2007) , p. 2563-2581
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