Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy - Search Results

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Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy / Aviñó, Ana (Institut de Química Avançada de Catalunya) ; Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ; Casanova Rigat, Isolda (Institut d'Investigació Biomèdica Sant Pau) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio, (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ; Eritja, Ramon (Institut de Química Avançada de Catalunya) ; Universitat Autònoma de Barcelona
Oligonucleotide-protein conjugates have important applications in biomedicine. Simple and efficient methods are described for the preparation of these conjugates. Specifically, we describe a new method in which a bifunctional linker is attached to thiol-oligonucleotide to generate a reactive intermediate that is used to link to the protein. [...]
2019 - DOI (Digital Object Identifier)

10.1002/open.201900038
ChemistryOpen, Vol. 8, issue 3 (March 2019) , p. 382-387

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