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Scopus: 17 cites, Web of Science: 13 cites,
Paracetamol in therapeutic dosages and acute liver injury : causality assessment in a prospective case series
Sabaté, Mònica (Vall d'Hebron Hospitals)
Ibáñez Mora, Luisa (Vall d'Hebron Hospitals)
Pérez, Eulàlia (Vall d'Hebron Hospitals)
Vidal, Xavier (Vall d'Hebron Hospitals)
Buti, Maria (Vall d'Hebron Hospitals)
Xiol, Xavier (Hospital Universitari Prínceps d'Espanya de Bellvitge)
Mas, Antoni (Hospital Clínic i Provincial de Barcelona)
Guarner, Carlos (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Forné, Montserrat (Hospital de Mútua (Terrassa, Catalunya))
Solà Lamoglia, Ricard (Hospital del Mar (Barcelona, Catalunya))
Castellote, José (Hospital Universitari Prínceps d'Espanya de Bellvitge)
Rigau, Joaquim (Hospital General (Granollers, Catalunya))
Laporte Rosselló, Joan-Ramón (Vall d'Hebron Hospitals)

Data: 2011
Resum: Background: Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug. The aim is to describe the characteristics of patients admitted to hospital with jaundice who had previous exposure to therapeutic doses of paracetamol. An assessment of the causality role of paracetamol was performed in each case. Methods: Based on the evaluation of prospectively gathered cases of ALI with detailed clinical information, thirty-two cases of ALI in non-alcoholic patients exposed to therapeutic doses of paracetamol were identified. Two authors assessed all drug exposures by using the CIOMS/RUCAM scale. Each case was classified into one of five categories based on the causality score for paracetamol. Results: In four cases the role of paracetamol was judged to be unrelated, in two unlikely, and these were excluded from evaluation. In seven of the remaining 26 cases, the RUCAM score associated with paracetamol was higher than that associated with other concomitant medications. The estimated incidence of ALI related to the use of paracetamol in therapeutic dosages was 0. 4 per million inhabitants older than 15 years of age and per year (99%CI, 0. 2-0. 8) and of 10 per million paracetamol users-year (95% CI 4. 3-19. 4). Conclusions:.
Resum: Our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; publishedVersion
Publicat a: BMC Gastroenterology, Vol. 11, N. 80 (July 2011) , p. 1-7, ISSN 1471-230X

DOI: 10.1186/1471-230X-11-80

7 p, 191.5 KB

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