Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma

Lavarino, Cinzia; Cheung, Nai-Kong V.; García, Idoia; Domènech Gómez, Gemma; Torres, Carmen de; Alaminos, Miguel; Ríos, José; Gerald, William L.; Kushner, Brian; LaQuaglia, Mike; Català-Mora, Jaume

doi:10.1186/1471-2407-9-44

Cita bibliogràfica -- Enllaç permanent: https://ddd.uab.cat/record/113554

Web of Science: 24 cites, Scopus: 24 cites, Google Scholar: cites,

Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma
Lavarino, Cinzia (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Cheung, Nai-Kong V. (Memorial Sloan Kettering Cancer Center)
García, Idoia (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Domènech Gómez, Gemma (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva)
Torres, Carmen de (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Alaminos, Miguel (Universidad de Granada. Departamento de Histología)
Ríos, José

(Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva)
Gerald, William L. (Memorial Sloan Kettering Cancer Center)
Kushner, Brian (Memorial Sloan Kettering Cancer Center)
LaQuaglia, Mike (Memorial Sloan Kettering Cancer Center)
Català-Mora, Jaume

(Hospital Sant Joan de Déu (Barcelona, Catalunya))

Data:	2009
Resum:	Background: Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for therapeutic decisions. The aim of this study was to investigate chromosomal alterations and differential gene expression amongst infant disseminated NB subgroups. Methods: Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage 4s), were evaluated by allelic and gene expression analyses. Results: All stage 4s patients underwent spontaneous remission, only 48% stage 4 patients survived despite combined modality therapy. Stage 4 tumours were 90% near-diploid/tetraploid, 44% MYCN amplified, 77% had 1p LOH (50% 1p36), 23% 11q and/or 14q LOH (27%) and 47% had 17q gain. Stage 4s were 90% near-triploid, none MYCN amplified and LOH was restricted to 11q. Initial comparison analyses between stage 4s and 4 < 12 months tumours revealed distinct gene expression profiles. A significant portion of genes mapped to chromosome 1 (P < 0. 0001), 90% with higher expression in stage 4s, and chromosome 11 (P = 0. 0054), 91% with higher expression in stage 4. Less definite expression profiles were observed between stage 4s and 4 < 18m, yet, association with chromosomes 1 (P < 0. 0001) and 11 (P = 0. 005) was maintained. Distinct gene expression profiles but no significant association with specific chromosomal region localization was observed between stage 4s and stage 4 < 18 months without MYCN amplification. Conclusion: Specific chromosomal aberrations are associated with distinct gene expression profiles which characterize spontaneously regressing or aggressive infant NB, providing the biological basis for the distinct clinical behaviour.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	BMC Cancer, Vol. 9, N. 44 (February 2009) , p. 1-11, ISSN 1471-2407