Per citar aquest document: http://ddd.uab.cat/record/142540
Role of IL-6 in Exercise Training- and Cold-Induced UCP1 Expression in Subcutaneous White Adipose Tissue
Knudsen, Jakob G. (University of Copenhagen. Department of Biology)
Murholm, Maria (University of Copenhagen. Department of Biology)
Carey, Andrew L. (Baker IDI Heart and Diabetes Institute (Melbourne, Austràlia))
Biensø, Rasmus S. (University of Copenhagen. Department of Biology)
Basse, Astrid L. (University of Copenhagen.Departament de Biologia)
Allen, Tamara L (Baker IDI Heart and Diabetes Institute (Melbourne, Austràlia))
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Kingwell, Bronwyn A. (Baker IDI Heart and Diabetes Institute (Melbourne, Austràlia))
Febbraio, Mark A. (Baker IDI Heart and Diabetes Institute (Melbourne, Austràlia))
Hansen, Jacob B. (University of Copenhagen. Department of Biology)
Pilegaard, Henriette (University of Copenhagen. Department of Biology)

Data: 2014
Resum: Expression of brown adipose tissue (BAT) associated proteins like uncoupling protein 1 (UCP1) in inguinal WAT (iWAT) has been suggested to alter iWAT metabolism. The aim of this study was to investigate the role of interleukin-6 (IL-6) in exercise training and cold exposure-induced iWAT UCP1 expression. The effect of daily intraperitoneal injections of IL-6 (3 ng/g) in C57BL/6 mice for 7 days on iWAT UCP1 expression was examined. In addition, the expression of UCP1 in iWAT was determined in response to 3 days of cold exposure (4°C) and 5 weeks of exercise training in wild type (WT) and whole body IL-6 knockout (KO) mice. Repeated injections of IL-6 in C57BL/6 mice increased UCP1 mRNA but not UCP1 protein content in iWAT. Cold exposure increased iWAT UCP1 mRNA content similarly in IL-6 KO and WT mice, while exercise training increased iWAT UCP1 mRNA in WT mice but not in IL-6 KO mice. Additionally, a cold exposure-induced increase in iWAT UCP1 protein content was blunted in IL-6 KO mice, while UCP1 protein content in iWAT was lower in both untrained and exercise trained IL-6 KO mice than in WT mice. In conclusion, repeated daily increases in plasma IL-6 can increase iWAT UCP1 mRNA content and IL-6 is required for an exercise training-induced increase in iWAT UCP1 mRNA content. In addition IL-6 is required for a full induction of UCP1 protein expression in response to cold exposure and influences the UCP1 protein content iWAT of both untrained and exercise trained animals.
Nota: Número d'acord de subvenció EC/FP7/278373
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Matèria: Brown adipose tissue ; STAT proteins ; Skeletal muscles ; Phosphorylation ; Intraperitoneal injections ; Blood plasma ; Body temperature ; Protein expression
Publicat a: PLoS one, Vol. 9 Issue 1 (January 2014) , p. e84910, ISSN 1932-6203

DOI: 10.1371/journal.pone.0084910


8 p, 1.1 MB

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