International veterinary epilepsy task force recommendations for systematic sampling andprocessing of brains from epileptic dogs and cats
Matiasek, Kaspar (Ludwig-Maximilians-Universität München)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Rosati, Marco (Ludwig-Maximilians-Universität München)
Fernández Flores, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Fischer, Andrea (University of Copenhagen)
Wagner, Eva (Ludwig-Maximilians-Universität München)
Berendt, Mette (University of Copenhagen)
Bhatti, Sofie F. M. (Ghent University. Department of Small Animal Medicine and Clinical Biology)
De Risio, Luisa (Animal Health Trust (Newmarket, Regne Unit))
Farqhuar, Robyn G. (Fernside Veterinary Centre (Borehamwood, Regne Unit))
Long, Sam (University of Melbourne)
Muñana, Karen (North Carolina State University)
Patterson, Edward E. (University of Minnesota. College of Veterinary Medicine)
Pakozdy, Akos (University of Veterinary Medicine (Viena, Àustria). Clinical Unit of Internal Medicine Small Animals)
Penderis, Jacques (Broadleys Veterinary Hospital (Stirling, Regne Unit))
Platt, Simon (University of Georgia. College of Veterinary Medicine)
Podell, Michael (Chicago Veterinary Neurology and Neurosurgery)
Potschka, Heidrun (Ludwig-Maximilians-Universität München)
Rusbridge, Clare (University of Surrey. School of Veterinary Medicine)
Stein, Veronika M. (University of Veterinary Medicine Hannover)
Tipold, Andrea (University of Veterinary Medicine Hannover)
Volk, Holger A. (University of London. Royal Veterinary College (Hatfield, Regne Unit))

Data:	2015
Resum:	Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals. The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures. Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements. The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Canine ; Feline ; Seizures ; Hippocampus ; Ictogenic ; Epileptogenic ; Processing ; Neuropathology
Publicat a:	BMC veterinary research, Vol. 11, Núm. 216 (August 2015) , p. 1-29, ISSN 1746-6148

DOI: 10.1186/s12917-015-0467-9
PMID: 26324339

29 p, 7.7 MB

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