Immunological Features of the Non-Structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus
Rascón Castelo, Edgar (Centro de Investigación en Alimentación y Desarrollo (Sonora, Mèxic))
Burgara Estrella, Alexel (Centro de Investigación en Alimentación y Desarrollo (Sonora, Mèxic))
Mateu de Antonio, Enrique María (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Hernández, Jesús (Centro de Investigación en Alimentación y Desarrollo (Sonora, Mèxic))

Data:	2015
Resum:	Porcine reproductive and respiratory syndrome virus (PRRSV) is currently one of the most important viruses affecting the swine industry worldwide. Despite the large number of papers published each year, the participation of non-structural proteins (nsps) in the immune response is not completely clear. nsps have been involved in the host innate immune response, specifically, nsp1α/β, nsp2, nsp4 and nsp11 have been associated with the immunomodulation capability of the virus. To date, only participation by nsp1, nsp2, nsp4 and nsp7 in the humoral immune response has been reported, with the role of other nsps being overlooked. Furthermore, nsp1, nsp2, nsp5, nsp7 nsp9, nsp10, nsp11 have been implicated in the induction of IFN-γ and probably in the development of the cell-mediated immune response. This review discusses recent reports involving the participation of nsps in the modulation of the innate immune response and their role in the induction of both the humoral and cellular immune responses.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	PRRSV ; Non-structural proteins ; Immune response
Publicat a:	Viruses, Vol. 7 (2015) , p. 873-886, ISSN 1999-4915

DOI: 10.3390/v7030873
PMID: 25719944

14 p, 532.9 KB

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