Immunohistochemical study of doublecortin and nucleostemin in canine brain
De Nevi, E. (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Marco-Salazar, P. (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Fondevila, Dolors (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Blasco, Ester. (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pérez Rodríguez, Lola (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Date:	2013
Abstract:	Finding a marker of neural stem cells remains a medical research priority. It was reported that the proteins doublecortin and nucleostemin were related with stem/progenitor cells in central nervous system. The aim of the present immunohistochemical study was to evaluate the expression of these proteins and their pattern of distribution in canine brain, including age-related changes, and in non-nervous tissues. We found that doublecortin had a more specific expression pattern, related with neurogenesis and neuronal migration, while nucleostemin was expressed in most cells of almost every tissue studied. The immunolabeling of both proteins decreased with age. We may conclude that nucleostemin is not a specific marker of stem/progenitor cells in the dog. Doublecortin, however, is not an exclusive marker of neural stem cells, but also of neuronal precursors.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Nucleostemin ; Doublecortin ; Stem cells ; Dog brain ; Aging
Published in:	European Journal of Histochemistry, Vol. 57 Núm. e9 (2013) , p. 55-59

Adreça alternativa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683616/
DOI: 10.4081/ejh.2013.e9
PMID: 23549468

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Unitat de Patologia Murina i Comparada
Articles > Research articles
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