Biological signatures of brain damage associated with high serum ferritin levels in patients with acute ischemic stroke and thrombolytic treatment
Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sobrino, Tomás
Arenillas, Juan F.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez-Yáñez, Manuel
García, María
Nombela, Florentino
Castellanos, María del Mar
Pérez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cuadras, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Fecha:	2008
Resumen:	Background and purpose : Increased body iron stores have been related to greater oxidative stress and brain injury in clinical and experimental cerebral ischemia and reperfusion. We aimed to investigate the biological signatures of excitotoxicity, inflammation and blood brain barrier disruption potentially associated with high serum ferritin levels-related damage in acute stroke patients treated with i. v. t-PA. Methods : Serum levels of ferritin (as index of increased cellular iron stores), glutamate, interleukin-6, matrix metalloproteinase-9 and cellular fibronectin were determined in 134 patients treated with i. v. t-PA within 3 hours from stroke onset in blood samples obtained before t-PA treatment, at 24 and 72 hours. Results : Serum ferritin levels before t-PA infusion correlated to glutamate (r = 0. 59, p < 0. 001) and interleukin-6 (r = 0. 55, p <0. 001) levels at baseline, and with glutamate (r = 0. 57, p <0. 001), interleukin-6 (r = 0. 49, p <0. 001), metalloproteinase-9 (r = 0. 23, p = 0. 007) and cellular fibronectin (r = 0. 27, p = 0. 002) levels measured at 24 hours and glutamate (r = 0. 415, p < 0. 001), interleukin-6 (r = 0. 359, p < 0. 001) and metalloproteinase-9 (r = 0. 261, p = 0. 004) at 72 hours. The association between ferritin and glutamate levels remained after adjustment for confounding factors in generalized linear models. Conclusions : Brain damage associated with increased iron stores in acute ischemic stroke patients treated with iv. tPA may be mediated by mechanisms linked to excitotoxic damage. The role of inflammation, blood brain barrier disruption and oxidative stress in this condition needs further research.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Ferro en l'organisme ; Malalties cerebrovasculars ; Iron stores ; Thrombolysis ; Ferritin ; Biomarkers ; Excitotoxicity ; Blood-brain-barrier disruption ; Inflammation
Publicado en:	Disease markers, Vol. 25 (12 2008) , p. 181-188, ISSN 1875-8630

DOI: 10.1155/2008/380356
PMID: 19096131

8 p, 333.4 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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