Muscular and glenohumeral changes in the shoulder after brachial plexus birth palsy : an MRI study in a rat model
Soldado Carrera, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Benito Castillo, David (Fundació Hospital de l'Esperit Sant. Cirurgia ortopèdica)
García Fontecha, César Galo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Barber Martínez de la Torre, Ignasi (Hospital Universitari Vall d'Hebron)
Marotta, Mario (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Haddad, Sleiman (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Menendez, Mariano E. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Mascarenhas, Vasco V. (Hospital da Luz. Centro de Imagiologia (Portugal))
Kozin, Scott H. (Temple University & Hand Surgeon. Shriners Hospital for Children. Department of Orthopaedic Surgery (USA))
Universitat Autònoma de Barcelona

Data:	2012
Resum:	Shoulder abnormalities are the major cause of morbidity in upper brachial plexus birth palsy (BPBP). We developed a rat model of upper trunk BPBP and compared our findings to previously reported animal models and to clinical findings in humans. Forty-three 5-day-old newborn rats underwent selective upper trunk neurectomy of the right brachial plexus and were studied 3 to 20 weeks after surgery. The passive shoulder external rotation was measured and the shoulder joint was assessed bilaterally by a 7. 2T MRI bilaterally. We found a marked decrease in passive shoulder external rotation, associated with a severe subscapularis muscle atrophy and contracture. None however developed the typical pattern of glenohumeral dysplasia. In contradiction with previous reports, our study shows that the rat model is not adequate for preclinical studies of shoulder dysplasia. However, it might serve as a useful model for studies analyzing shoulder contracture occurring after upper BPBP.
Ajuts:	Instituto de Salud Carlos III FIS/PI10/01357
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Shoulder anomalies following brachial plexus birth palsy ; Shoulder internal rotation contracture ; Glenohumeral dysplasia ; Erb's palsy
Publicat a:	Journal of Brachial Plexus and Peripheral Nerve Injury, Vol. 7 (December 2012) , art. 9, ISSN 1749-7221

DOI: 10.1186/1749-7221-7-9
PMID: 23217052

7 p, 1.7 MB

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