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Página principal > Artículos > Artículos publicados > Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens |
Fecha: | 2017 |
Resumen: | Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here. |
Ayudas: | Instituto de Salud Carlos III PI15CIII/00024 Ministerio de Economía y Competitividad SAF2015-67033-R Ministerio de Economía y Competitividad BFU2014-57797-R Ministerio de Economía y Competitividad SAF2015-65307-R Ministerio de Economía y Competitividad SAF2012-39444-C01/02 Ministerio de Economía y Competitividad SAF2012-39841 Ministerio de Economía y Competitividad SAF2015-66520-R Ministerio de Economía y Competitividad BFU2015-70052-R European Commission PITN-GA-2012-317297 Ministerio de Economía y Competitividad BES-2013-065355 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Respiratory pathogens ; Host response ; Core of up-regulated genes ; Bacterial infections ; Viral infections |
Publicado en: | Frontiers in microbiology, Vol. 8 (2017) , p. 1-13, ISSN 1664-302X |
13 p, 2.4 MB |