Trends in detection of invasive cancer and ductal carcinoma in situ at biennial screening mammography in spain : A retrospective cohort study
Román, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Rué, Montse (Institut de Recerca Biomèdica de Lleida)
Sala, Maria (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Ascunce, Nieves (Instituto de Salud Pública de Navarra)
Baré i Mañas, Marisa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Baroja, Araceli (Fundacion Rioja Salud)
la Vega Prieto, Mariola de (Dirección General de Programas Asistenciales. Consejería de Sanidad. Servicio Canario de Salud)
Galceran, Jaume (Institut d'Investigació Sanitària Pere Virgili)
Natal, Carmen (Oficina de Salud, Oviedo)
Salas, Dolores (Direcció General de Salut Pública. València)
Sánchez Jacob, Mercedes (Servicio de Promoción de la Salud Y Programas Preventivos. Consejería de Sanidad de Castilla y León)
Zubizarreta Alberdi, Raquel (Dirección General de Salud Pública de Galicia)
Castells, Xavier (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC))
Blanch, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques)
Romero, Anabel (Institut Hospital del Mar d'Investigacions Mèdiques)
Almazán, Raquel (Dirección General de Salud Pública de Galicia)
Fernández, Ana Belén (Dirección General de Salud Pública de Galicia)
Queiro, María Teresa (Dirección General de Salud Pública de Galicia)
Delfrade, Iosu (Instituto de Salud Pública de Navarra)
Ederra, María (Instituto de Salud Pública de Navarra)
Erdozain, Nieves (Instituto de Salud Pública de Navarra)
Vidán, Juana (Instituto de Salud Pública de Navarra)
Ibáñez, Josefa (Direcció General de Salut Pública. València)
Cuevas, Dolores (Agència Valenciana de Salut)
la Vega, María Obdulia de (Servicio Canario de la Salud)
la Lastra, Isabel Díez de (Servicio Canario de la Salud)
González Román, Isabel (Dirección General de Salud Pública de Castilla-Leon)
Cumulative False Positive Risk Group

Date:	2013
Abstract:	Background: Breast cancer incidence has decreased in the last decade, while the incidence of ductal carcinoma in situ (DCIS) has increased substantially in the western world. The phenomenon has been attributed to the widespread adaption of screening mammography. The aim of the study was to evaluate the temporal trends in the rates of screen detected invasive cancers and DCIS, and to compare the observed trends with respect to hormone replacement therapy (HRT) use along the same study period. Methods: Retrospective cohort study of 1,564,080 women aged 45-69 years who underwent 4,705,681 screening mammograms from 1992 to 2006. Age-adjusted rates of screen detected invasive cancer, DCIS, and HRT use were calculated for first and subsequent screenings. Poisson regression was used to evaluate the existence of a change-point in trend, and to estimate the adjusted trends in screen detected invasive breast cancer and DCIS over the study period. Results: The rates of screen detected invasive cancer per 100. 000 screened women were 394. 0 at first screening, and 229. 9 at subsequent screen. The rates of screen detected DCIS per 100. 000 screened women were 66. 8 at first screen and 43. 9 at subsequent screens. No evidence of a change point in trend in the rates of DCIS and invasive cancers over the study period were found. Screen detected DCIS increased at a steady 2. 5% per year (95% CI: 1. 3; 3. 8), while invasive cancers were stable. Conclusion: Despite the observed decrease in breast cancer incidence in the population, the rates of screen detected invasive cancer remained stable during the study period. The proportion of DCIS among screen detected breast malignancies increased from 13% to 17% throughout the study period. The rates of screen detected invasive cancer and DCIS were independent of the decreasing trend in HRT use observed among screened women after 2002.
Grants:	Instituto de Salud Carlos III PI11/01296 Instituto de Salud Carlos III PI09/90251
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 8 Núm. 12 (23 2013) , p. e83121, ISSN 1932-6203

DOI: 10.1371/journal.pone.0083121
PMID: 24376649

8 p, 397.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles