Clinical validation of eye vergence as an objective marker for diagnosis of ADHD in children
Varela Casal, Paloma (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Esposito, Flavia Lorena (Universitat de Barcelona)
Morata Martínez, Imanol (Universitat Politècnica de Catalunya)
Capdevila, Alba (Hospital de Mataró. Consorci Sanitari del Maresme)
Solé Puig, Maria (Universitat de Barcelona)
Osa, Nuria de la (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Ezpeleta, Lourdes (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Perera Lluna, Alexandre (Universitat Politècnica de Catalunya)
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Supèr, Hans (Universitat de Barcelona)
Cañete-Crespillo, Josep (Hospital de Mataró. Consorci Sanitari del Maresme)

Date:	2018
Abstract:	Objective: ADHD youth show poor oculomotor control. Recent research shows that attention-related eye vergence is weak in ADHD children. Method: To validate vergence as a marker to classify ADHD, we assessed the modulation in the angle of vergence of children (n = 43) previously diagnosed with ADHD while performing an attention task and compared the results with age-matched clinical controls (n = 19) and healthy peers (n = 30). Results: We observed strong vergence responses in healthy participants and weak vergence in the clinical controls. ADHD children showed no significant vergence responses. Machine-learning models classified ADHD patients (n = 21) from healthy controls (n = 21) with an accuracy of 96. 3% (false positive [FP]: 5. 12%; false negative [FN]: 0%; area under the curve [AUC]: 0. 99) and ADHD children (n = 11) from clinical controls (n = 14) with an accuracy of 85. 7% (FP: 4. 5%; FN: 19. 2%, AUC: 0. 90). Conclusion: In combination with an attention task, vergence responses can be used as an objective marker to detect ADHD in children.
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	ADHD ; Eye vergence ; Diagnosis ; Children ; Biomarker ; Binocular
Published in:	Journal of attention disorders, 2018 , ISSN 1557-1246

DOI: 10.1177/1087054717749931

Post-print 42 p, 3.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Research group Epidemiology and Diagnosis in Psychopathology of Development (UED)
Articles > Research articles
Articles > Published articles