Circulating levels of 423-5p are associated with 90 day mortality in cardiogenic shock
Jäntti, Toni (Helsinki University Hospital (Finlàndia))
Segersvärd, Heli (Minerva Foundation Institute for Medical Research and University of Helsinki)
Tolppanen, Heli (Helsinki University Hospital (Finlàndia))
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia))
Lassus, Johan (Helsinki University Hospital (Finlàndia))
Devaux, Yvan (Luxembourg Institute of Health)
Vausort, Mélanie (Luxembourg Institute of Health)
Pulkki, Kari (Department of Clinical Chemistry, University of Eastern Finland and Eastern Finland Laboratory Centre (ISLAB))
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau)
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tikkanen, Ilkka (Helsinki University Hospital (Finlàndia))
Lakkisto, Päivi (Helsinki University Hospital (Finlàndia))
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia))
Universitat Autònoma de Barcelona. Departament de Medicina

Fecha:	2018
Resumen:	The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR-423-5p level to predict mortality and associations of miR-423-5p with prognostic markers in cardiogenic shock. We conducted a prospective multinational observational study enrolling consecutive cardiogenic shock patients. Blood samples were available for 179 patients at baseline to determine levels of miR-423-5p and other biomarkers. Patients were treated according to local practice. Main outcome was 90 day all-cause mortality. Median miR-423-5p level was significantly higher in 90 day non-survivors [median 0. 008 arbitrary units (AU) (interquartile range 0. 003-0. 017) vs. 0. 004 AU (0. 002-0. 009), P = 0. 003]. miR-423-5p level above median was associated with higher lactate (median 3. 7 vs. 2. 4 mmol/L, P = 0. 001) and alanine aminotransferase levels (median 68 vs. 35 IU/L, P < 0. 001) as well as lower cardiac index (1. 8 vs. 2. 4, P = 0. 04) and estimated glomerular filtration rate (56 vs. 70 mL/min/1. 73 m 2, P = 0. 002). In Cox regression analysis, miR-423-5p level above median was associated with 90 day all-cause mortality independently of established risk factors of cardiogenic shock [adjusted hazard ratio 1. 9 (95% confidence interval 1. 2-3. 2), P = 0. 01]. In cardiogenic shock patients, above median level of miR-423-5p at baseline is associated with markers of hypoperfusion and seems to independently predict 90 day all-cause mortality.
Nota:	Ajuts: This work was supported by grants from the Finnish Foundation for Cardiovascular Research, Aarne Koskelo Foundation, Finnish Foundation for Laboratory Medicine, FinskaLäkaresällskapet, the Liv och Hälsa Foundation, and Finnish state funding for university-level research.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; Versió publicada
Materia:	Cardiogenic shock ; Microrna ; Mir-423-5p ; Acute coronary syndrome ; Mortality ; Prognosis
Publicado en:	ESC Heart Failure, Vol. 6 (november 2018) , p. 98-102, ISSN 2055-5822

DOI: 10.1002/ehf2.12377
PMID: 30472788

5 p, 173.0 KB

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