Home > Articles > Published articles > Phytochrome and retrograde signalling pathways converge to antagonistically regulate a light-induced transcriptional network |
Date: | 2016 |
Abstract: | Plastid-to-nucleus retrograde signals emitted by dysfunctional chloroplasts impact photomorphogenic development, but the molecular link between retrograde-and photosensory-receptor signalling has remained unclear. Here, we show that the phytochrome and retrograde signalling (RS) pathways converge antagonistically to regulate the expression of the nuclear-encoded transcription factor GLK1, a key regulator of a light-induced transcriptional network central to photomorphogenesis. GLK1 gene transcription is directly repressed by PHYTOCHROME-INTERACTING FACTOR (PIF)-class bHLH transcription factors in darkness, but light-activated phytochrome reverses this activity, thereby inducing expression. Conversely, we show that retrograde signals repress this induction by a mechanism independent of PIF mediation. Collectively, our data indicate that light at moderate levels acts through the plant's nuclear-localized sensory-photoreceptor system to induce appropriate photomorphogenic development, but at excessive levels, sensed through the separate plastid-localized RS system, acts to suppress such development, thus providing a mechanism for protection against photo-oxidative damage by minimizing the tissue exposure to deleterious radiation. |
Grants: | Ministerio de Ciencia e Innovación BIO2009-07675 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-206 Ministerio de Economía y Competitividad BIO2012-31672 Ministerio de Economía y Competitividad BIO2012-31860 Ministerio de Educación, Cultura y Deporte PRX12/00631 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Arabidopsis ; Arabidopsis Proteins ; Basic Helix-Loop-Helix Transcription Factors ; Darkness ; Gene Expression Regulation, Plant ; Gene Regulatory Networks ; Light ; Morphogenesis ; Phytochrome ; Plastids ; Signal Transduction ; Transcription Factors |
Published in: | Nature communications, Vol. 7 (May 2016) , art. 11431, ISSN 2041-1723 |
10 p, 1.1 MB |