CRAG (Centre for Research in Agricultural Genomics)

The CRAG is devoted to leading-edge research in the molecular basis of genetic characters of interest in plants and farm animals and in the applications of molecular approaches for breeding of species important for agriculture and food production. Research at CRAG spans from basic science to applied studies in close collaboration with industry.

 

Latest additions:
2018-07-12
12:54
22 p, 8.6 MB The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei / Rojas, Federico (Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (Buenos Aires)) ; Koszela, Joanna (University of Edinburgh Medical School. College of Medicine and Veterinary Medicine) ; Búa, Jacqueline E. (Instituto Nacional de Diagnostico e Investigacion de la Enfermedad de Chagas Dr. Mario Fatala Chaben) ; Llorente, Briardo (Centre de Recerca en Agrigenòmica) ; Burchmore, Richard Js (University of Glasgow. Institute of Infection, Immunity and Inflammation) ; Auer, Manfred (University of Edinburgh Medical School. College of Medicine and Veterinary Medicine) ; Mottram, Jeremy C. (University of York. Department of Biology) ; Téllez-Iñón, María Teresa (Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (Buenos Aires))
The ubiquitin-proteasome system is a post-translational regulatory pathway for controlling protein stability and activity that underlies many fundamental cellular processes, including cell cycle progression. [...]
2017 - 10.1371/journal.pntd.0005626
PLoS neglected tropical diseases, Vol. 11 Núm. 6 (2017) , e0005626  
2018-07-12
11:30
14 p, 1.1 MB An artificial miRNA system reveals that relative contribution of translational inhibition to miRNA-mediated regulation depends on environmental and developmental factors in Arabidopsis thaliana / Von Born, Patrick (Max Planck Institute for Plant Breeding Research. Department of Plant-Microbe Interactions,) ; Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ; Rubio-Somoza, Ignacio (Centre de Recerca en Agrigenòmica)
Development and fitness of any organism rely on properly controlled gene expression. This is especially true for plants, as their development is determined by both internal and external cues. MicroRNAs (miRNAs) are embedded in the genetic cascades that integrate and translate those cues into developmental programs. [...]
2018 - 10.1371/journal.pone.0192984
Plos One, Vol. 13 No. 2 (2018) , e0192984  
2018-07-12
11:22
16 p, 18.4 MB The GARP/MYB-related grape transcription factor AQUILO improves cold tolerance and promotes the accumulation of raffinose family oligosaccharides / Sun, Xiaoming (Chinese Academy of Sciences. Beijing Key Laboratory of Grape Sciences and Enology) ; Matus, José Tomás (Centre de Recerca en Agrigenòmica) ; Wong, Darren Chern Jan (Australian National University. Research School of Biology. Ecology and Evolution) ; Wang, Zemin (Chinese Academy of Sciences. Beijing Key Laboratory of Grape Sciences and Enology) ; Chai, Fengmei (Chinese Academy of Sciences. Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture) ; Zhang, Langlang (Chinese Academy of Sciences. Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture) ; Fang, Ting Ting (Chinese Academy of Sciences. Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture) ; Zhao, Li (Chinese Academy of Sciences. Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture) ; Wang,Yi (Chinese Academy of Sciences. Beijing Key Laboratory of Grape Sciences and Enology) ; Han, Yuepeng (Chinese Academy of Sciences. Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture) ; Wang, Qingfeng (Chinese Academy of Sciences. Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture) ; Li, Shaohua (Chinese Academy of Sciences. Beijing Key Laboratory of Grape Sciences and Enology) ; Liang, Zhenchang (Chinese Academy of Sciences. Beijing Key Laboratory of Grape Sciences and Enology) ; Xin, Haiping (Chinese Academy of Sciences. Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture)
Grapevine (Vitis vinifera L. ) is a widely cultivated fruit crop whose growth and productivity are greatly affected by low temperatures. On the other hand, wild Vitis species represent valuable genetic resources of natural stress tolerance. [...]
2018 - 10.1093/jxb/ery020
Journal of experimental botany, Vol. 69 Núm. 7 (March 2018) , p. 1749-1764  
2018-06-25
14:27
22 p, 2.1 MB “Mutants plants” workshop protocol : didactic guide for researchers and instructors to conduct a science workshop with groups of school students aged 10 to 14. / Babot, Zoila (Centre de Recerca en Agrigenòmica) ; Martí, Margalida (Centre de Recerca en Agrigenòmica) ; Garrido Espeja, Anna (Universitat Autònoma de Barcelona. Centre de Recerca per a l'Educació Científica i Matemàtica) ; Tena Gallego, Èlia (Universitat Autònoma de Barcelona. Centre de Recerca per a l'Educació Científica i Matemàtica) ; Centre de Recerca en Agrigenòmica ; Universitat Autònoma de Barcelona. Centre de Recerca per a l'Educació Científica i Matemàtica
The “Mutant Plants” workshop pursues the dual aim of promoting scientific vocations and publicizing the importance of Plant Science to meet current and future societal challenges. This workshop was designed jointly by the Centre for Research in Agricultural Genomics (CRAG) and the Research Centre for Scientific and Mathematical Education (CRECIM) from the Autonomous University of Barcelona (UAB), thanks to the financial support of the Spanish Foundation for Science and Technology (FCT-16-10825) and the Severo Ochoa program of Excellence Centres (SEV‐2015‐0533), both from the Spanish Ministry of Economy, Industry and Competitiveness.
2017  
2018-06-18
04:06
11 p, 563.4 KB Plant lineage-specific amplification of transcription factor binding motifs by miniature inverted-repeat transposable elements (MITEs) / Morata, Jordi (Centre de Recerca en Agrigenòmica) ; Marín Nieto, Fátima (Centre de Recerca en Agrigenòmica) ; Payet, Jordi ; Casacuberta, Josep Maria (Centre de Recerca en Agrigenòmica)
Transposable elements are one of the main drivers of plant genome evolution. Transposon insertions can modify the gene coding capacity or the regulation of their expression, the latter being a more subtle effect, and therefore particularly useful for evolution. [...]
2018 - 10.1093/gbe/evy073
Genome biology and evolution, Vol. 10, issue 5 (May 2018) , p. 1210-1220  
2018-06-18
04:06
16 p, 2.8 MB The Polycistronic miR166k-166h positively regulates rice immunity via post-transcriptional control of EIN2 / Salvador Guirao, Raquel (Centre de Recerca en Agrigenòmica) ; Hsing, Yue-ie (Academia Sinica. Institute of Plant and Microbial Biology) ; San Segundo, Blanca (Centre de Recerca en Agrigenòmica)
MicroRNAs (miRNAs) are small RNAs acting as regulators of gene expression at the post-transcriptional level. In plants, most miRNAs are generated from independent transcriptional units, and only a few polycistronic miRNAs have been described. [...]
2018 - 10.3389/fpls.2018.00337
Frontiers in plant science, Vol. 9 (March 2018) , art. 337  
2018-06-18
04:06
6 p, 1.8 MB Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart / Sánchez-Iranzo, Héctor (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ; Galardi-Castilla, María (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ; Sanz-Morejón, Andrés (Universität Bern) ; González-Rosa, Juan Manuel (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ; Costa, Ricardo (Centre de Recerca en Agrigenòmica) ; Ernst, Alexander (Universität Bern) ; Sainz de Aja, Julio (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ; Langa, Xavier (Universität Bern) ; Mercader, Nadia (Universität Bern) ; Institut de Recerca i Tecnologia Agroalimentàries
After myocardial infarction in the mammalian heart, millions of cardiomyocytes are lost and replaced by fibrotic scar tissue. While fibrosis is persistent in adult mammals, there are some vertebrates, including zebrafish, with the capacity for regeneration. [...]
2018 - 10.1073/pnas.1716713115
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, issue 16 (April 2018) , p. 4188-4193  
2018-06-18
04:06
14 p, 1.3 MB An integrated approach for increasing breeding efficiency in apple and peach in Europe / Laurens, Francois (Institut National Recherche Agronomique) ; Aranzana Civit, María José (Centre de Recerca en Agrigenòmica) ; Arús i Gorina, Pere (Centre de Recerca en Agrigenòmica) ; Bassi, Daniele (Università degli Studi di Milano) ; Bink, Marco (Wageningen University and Research. Biometris) ; Bonany, Joan (Institut de Recerca i Tecnologia Agroalimentàries) ; Caprera, Andrea (Parco Tecnologico Padano) ; Corelli-Grappadelli, Luca (Università di Bologna. Dipartimento di Scienze Agrarie) ; Costes, Evelyne (Institut National Recherche Agronomique) ; Durel, Charles-Eric (Institut National Recherche Agronomique) ; Mauroux, Jehan-Baptiste (Institut National Recherche Agronomique) ; Muranty, Hélène (Institut National Recherche Agronomique) ; Nazzicari, Nelson (Parco Tecnologico Padano) ; Pascal, Thierry (Institut National Recherche Agronomique) ; Patocchi, Andrea (Agroscope. Research Division Plant Breeding (Switzerland)) ; Peil, Andreas (Julius Kühn-Institute Research) ; Quilot-Turion, Bénédicte (Institut National Recherche Agronomique) ; Rossini, Laura (Parco Tecnologico Padano-) ; Stella, Alessandra (Parco Tecnologico Padano-) ; Troggio, Michela (Fondazione Edmund Mach. Research and Innovation Center) ; Velasco, Riccardo (Fondazione Edmund Mach. Research and Innovation Center) ; van de Weg, Eric (Wageningen University and Research)
Despite the availability of whole genome sequences of apple and peach, there has been a considerable gap between genomics and breeding. To bridge the gap, the European Union funded the FruitBreedomics project (March 2011 to August 2015) involving 28 research institutes and private companies. [...]
2018 - 10.1038/s41438-018-0016-3
Horticulture Research, Vol. 5 (March 2018) , art. 11  
2018-03-13
13:57
25 p, 1.2 MB A generalized Watterson estimator for next-generation sequencing : from trios to autopolyploids / Ferretti, Luca (Université Pierre et Marie CURIE) ; Ramos Onsins, Sebastián E. (Centre de Recerca en Agrigenòmica)
Several variations of the Watterson estimator of variability for Next Generation Sequencing (NGS) data have been proposed in the literature. We present a unified framework for generalized Watterson estimators based on Maximum Composite Likelihood, which encompasses most of the existing estimators. [...]
2015 - 10.1016/j.tpb.2015.01.001
Theoretical population biology, Vol. 100 (March 2015) , p. 79-87  
2018-03-13
13:46
38 p, 1.7 MB Transposon insertions, structural variations, and SNPs contribute to the evolution of the melon genome / Sanseverino, Walter (Centre de Recerca en Agrigenòmica) ; Hénaff, Elizabeth (Centre de Recerca en Agrigenòmica) ; Vives, Cristina (Centre de Recerca en Agrigenòmica) ; Pinosio, Sara (Universita degli studi di Udine. Dipartimento di szience agrarie e ambientali) ; Burgos-Paz, William (Centre de Recerca en Agrigenòmica) ; Morgante, Michele (Universita degli studi di Udine. Dipartimento di szience agrarie e ambientali) ; Ramos Onsins, Sebastián E. (Centre de Recerca en Agrigenòmica) ; Garcia Mas, Jordi (Centre de Recerca en Agrigenòmica) ; Casacuberta, Josep Maria (Centre de Recerca en Agrigenòmica)
The availability of extensive databases of crop genome sequences should allow analysis of crop variability at an unprecedented scale, which should have an important impact in plant breeding. However, up to now the analysis of genetic variability at the whole-genome scale has been mainly restricted to single nucleotide polymorphisms (SNPs). [...]
2015 - 10.1093/molbev/msv152
Molecular biology and evolution, Vol. 32, issue 10 (Oct. 2015) , p. 2760-74