Single and longitudinal genome-wide association studies for dairy traits available in goats with three recorded lactations
Luigi Sierra, Maria Gracia (Centre de Recerca en Agrigenòmica)
Martínez, Amparo (Universidad de Córdoba. Departamento de Genética)
Macri, Martina (Universidad de Córdoba. Departamento de Genética)
Delgado, Juan Vicente (Universidad de Córdoba. Departamento de Genética)
Castelló Farré, Anna (Centre de Recerca en Agrigenòmica)
Fernández Álvarez, Javier (Asociación Nacional de Criadores de Caprino de Raza Murciano-Granadina)
Such i Martí, Francesc Xavier (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Jordana i Vidal, Jordi (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Date:	2024
Abstract:	Milk yield and composition phenotypes are systematically recorded across several lactations in goats, but the majority of genome-wide association studies (GWAS) performed so far have rather ignored the longitudinal nature of such data. Here, we have used two different GWAS approaches to analyse data from three lactations recorded in Murciano-Granadina goats. In Analysis 1, independent GWAS have been carried out for each trait and lactation, while a single longitudinal GWAS, jointly considering all data, has been performed in Analysis 2. In both analyses, genome-wide significant QTL for lactose percentage on chromosome 2 (129. 77-131. 01 Mb) and for milk protein percentage on the chromosome 6 (74. 8-94. 6 Mb) casein gene cluster region were detected. In Analysis 1, several QTL were not replicated in all three lactations, possibly due to the existence of lactation-specific genetic determinants. In Analysis 2, we identified several genome-wide significant QTL related to milk yield and protein content that were not uncovered in Analysis 1. The increased number of QTL identified in Analysis 2 suggests that the longitudinal GWAS is particularly well suited for the genetic analysis of dairy traits. Moreover, our data confirm that variability within or close to the casein complex is the main genetic determinant of milk protein percentage in Murciano-Granadina goats.
Grants:	Ministerio de Ciencia e Innovación PID2022-136834OB-I00 Ministerio de Ciencia e Innovación PID2019-105805RB-I00 Ministerio de Ciencia e Innovación CEX2019-000902-S Ministerio de Economía y Competitividad BES-2017-079709
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	GWAS ; Milk yield and composition traits ; Murciano-Granadina breed
Published in:	Animal Genetics, Vol. 55, Núm. 2 (April 2024) , p. 257-264, ISSN 1365-2052
Related work:	Luigi-Sierra et al. 2023. Single and longitudinal genome-wide association studies for dairy traits available in goats with three recorded lactations. Animal Genetics,2024, CORA.Repositori de Dades de Recerca https://doi.org/10.34810/data1153

DOI: 10.1111/age.13391

8 p, 1.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Research articles
Articles > Published articles