Test-retest reliability of the effects of continuous theta-burst stimulation
Jannati, Ali (Berenson-Allen Center for Noninvasive Brain Stimulation. Division of Cognitive Neurology. Department of Neurology. Harvard Medical School)
Fried, P. J. (Berenson-Allen Center for Noninvasive Brain Stimulation. Division of Cognitive Neurology. Department of Neurology. Harvard Medical School)
Block, G. (School of Medicine. New York Medical College)
Oberman, L. M. (Department of Medical and Clinical Psychology. Uniformed Services University of Health Sciences)
Rotenberg, Alexander (Boston Children's Hospital (Boston, Estats Units d'Amèrica))
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Universitat Autònoma de Barcelona

Fecha:	2019
Resumen:	Objectives: The utility of continuous theta-burst stimulation (cTBS) as index of cortical plasticity is limited by inadequate characterization of its test-retest reliability. We thus evaluated the reliability of cTBS aftereffects, and explored the roles of age and common single-nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) genes. Methods: Twenty-eight healthy adults (age range 21-65) underwent two identical cTBS sessions (median interval = 9. 5 days) targeting the motor cortex. Intraclass correlation coefficients (ICCs) of the log-transformed, baseline-corrected amplitude of motor evoked potentials (ΔMEP) at 5-60 min post-cTBS (T5-T60) were calculated. Adjusted effect sizes for cTBS aftereffects were then calculated by taking into account the reliability of each cTBS measure. Results: ΔMEP at T50 was the most-reliable cTBS measure in the whole sample (ICC = 0. 53). Area under-the-curve (AUC) of ΔMEPs was most reliable when calculated over the full 60 min post-cTBS (ICC = 0. 40). cTBS measures were substantially more reliable in younger participants (< 35 years) and in those with BDNF Val66Val and APOE ϵ4-genotypes. Conclusion: CTBS aftereffects are most reliable when assessed 50 min post-cTBS, or when cumulative ΔMEP measures are calculated over 30-60 min post-cTBS. Reliability of cTBS aftereffects is influenced by age, and BDNF and APOE polymorphisms. Reliability coefficients are used to adjust effect-size calculations for interpretation and planning of cTBS studies.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	APOE ; BDNF ; Continuous theta-burst stimulation ; Plasticity ; Reliability ; Transcranial magnetic stimulation
Publicado en:	Frontiers in Neuroscience, Vol. 13 Núm. MAY (2019) , p. 447, ISSN 1662-453X

DOI: 10.3389/fnins.2019.00447
PMID: 31156361

16 p, 1.3 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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