A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma
Hernández-Ruiz, Eugenia (Hospital del Mar (Barcelona, Catalunya))
Hernández-Muñoz, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques)
Masferrer, Emili (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Ferrandiz-Pulido, Carla (Hospital Universitari Vall d'Hebron)
Andrades, Evelyn (Institut Hospital del Mar d'Investigacions Mèdiques)
Gimeno, Javier (Hospital del Mar (Barcelona, Catalunya))
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
García-Patos Briones, Vicente (Universitat Autònoma de Barcelona. Departament de Medicina)
Pujol Vallverdú, Ramón M (Hospital del Mar (Barcelona, Catalunya))
Toll Abelló, Agustí (Hospital del Mar (Barcelona, Catalunya))

Data:	2018
Resum:	Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Clinical and histopathological data were registered. The fibrotic reaction pattern was classified as mature, intermediate or immature depending on the presence of keloid-like collagen and myxoid stroma. The immature pattern (areas characterized by myxoid changes with no inflamma-tion) was observed in 18 samples and its presence was significantly associated with immunosuppression, budding, desmoplasia, perineural invasion, anatomic level, tumoural depth and metastatic risk in the multivariate analysis. Our findings suggest that the presence of an immature myxoid fibrotic pattern, which can be easily identified by routine hematoxylin-eosin staining, is strongly associated with metastatic risk.
Ajuts:	Instituto de Salud Carlos III PI15-00236
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Metastasis ; Fibrosis ; Cutaneous squamous cell carcinoma
Publicat a:	Acta dermato-venereologica, Vol. 99 Núm. 1 (january 2018) , p. 89-94, ISSN 1651-2057

DOI: 10.2340/00015555-3025
PMID: 30176040

6 p, 3.7 MB

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