Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults
Vannini, Patrizia (Harvard Medical School)
Uquillas, F. d. O. (Massachusetts General Hospital (Boston))
Jacobs, H. I. L. (Massachusetts General Hospital (Boston))
Sepulcre, Jorge (Massachusetts General Hospital (Boston))
Gatchel, J. (Massachusetts General Hospital (Boston))
Amariglio, Rebecca (Harvard Medical School)
Hanseeuw, Bernard (Université Catholique de Louvain. Institute of Neurosciences)
Papp, K. V. (Massachusetts General Hospital (Boston))
Hedden, T. (Icahn School of Medicine at Mount Sinai)
Rentz, D. M. (Harvard Medical School)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Johnson, K. A. (Massachusetts General Hospital (Boston))
Sperling, R. A. (Harvard Medical School)
Universitat Autònoma de Barcelona

Fecha:	2019
Resumen:	The ability to accurately judge memory efficiency (meta-memory monitoring) for newly learned (episodic) information, is decreased in older adults and even worse in Alzheimer's disease (AD), whereas no differences have been found for semantic meta-memory. The pathological substrates of this phenomenon are poorly understood. Here, we examine the association between meta-memory monitoring for episodic and semantic information to the two major proteinopathies in AD: amyloid (Aβ) and tau pathology in a group of cognitively unimpaired older adults. All participants underwent multi-tracer PET and meta-memory monitoring was assessed using a feeling-of-knowing (FOK) task for non-famous (episodic) and famous (semantic) face-name pairs. Whole brain voxel-wise correlations between meta-memory and PET data were conducted (controlling for memory), as well as confirmatory region-of-interest analyses. Participants had reduced episodic FOK compared to semantic FOK. Decreased episodic FOK was related to tauopathy in the medial temporal lobe regions, including the entorhinal cortex and temporal pole, whereas decreased semantic FOK was related to increased tau in regions associated with the semantic knowledge network. No association was found with Aβ-pathology. Alterations in the ability to accurately judge memory efficiency (in the absence of memory decline) may be a sensitive clinical indicator of AD pathophysiology in the pre-symptomatic phase.
Ayudas:	European Commission 706714
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Alzheimer's disease ; Amyloid ; Feeling-of-knowing ; Meta-memory ; Tau
Publicado en:	NeuroImage, Vol. 24 (2019) , p. 102097, ISSN 2213-1582

DOI: 10.1016/j.nicl.2019.102097
PMID: 31795044

8 p, 1.2 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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