Reduction of intratumoral brain perfusion by noninvasive transcranial electrical stimulation
Sprugnoli, G. (Brain Investigation and Neuromodulation Laboratory. Department of Medicine. Surgery and Neuroscience. Unit of Neurology and Clinical Neurophysiology. Siena Medical School)
Monti, L. (Unit of Neuroimaging and Neurointervention. "Santa Maria Alle Scotte" Medical Center)
Lippa, L. (Unit of Neurosurgery. "Santa Maria Alle Scotte" Medical Center)
Neri, F. (Brain Investigation and Neuromodulation Laboratory. Department of Medicine. Surgery and Neuroscience. Unit of Neurology and Clinical Neurophysiology. Siena Medical School)
Mencarelli, L. (Brain Investigation and Neuromodulation Laboratory. Department of Medicine. Surgery and Neuroscience. Unit of Neurology and Clinical Neurophysiology. Siena Medical School)
Ruffini, G. (Neuroelectrics)
Salvador, R. (Neuroelectrics)
Oliveri, G. (Unit of Neurosurgery. "Santa Maria Alle Scotte" Medical Center)
Batani, B. (Unit of Neurosurgery. "Santa Maria Alle Scotte" Medical Center)
Momi, Davide (Brain Investigation and Neuromodulation Laboratory. Department of Medicine. Surgery and Neuroscience. Unit of Neurology and Clinical Neurophysiology. Siena Medical School)
Cerase, A. (Unit of Neuroimaging and Neurointervention. "Santa Maria Alle Scotte" Medical Center)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Rossi, A. (Department of Medicine. Surgery and Neuroscience. Human Physiology Section. Siena Medical School)
Rossi, S. (Department of Medicine. Surgery and Neuroscience. Human Physiology Section. Siena Medical School)
Santarnecchi, E. (Berenson-Allen Center for Noninvasive Brain Stimulation. Beth Israel Medical Center. Harvard Medical School)
Universitat Autònoma de Barcelona

Fecha:	2019
Resumen:	Malignant brain neoplasms have a poor prognosis despite aggressive treatments. Animal models and evidence from human bodily tumors reveal that sustained reduction in tumor perfusion via electrical stimulation promotes tumor necrosis, therefore possibly representing a therapeutic option for patients with brain tumors. Here, we demonstrate that transcranial electrical stimulation (tES) allows to safely and noninvasively reduce intratumoral perfusion in humans. Selected patients with glioblastoma or metastasis underwent tES, while perfusion was assessed using magnetic resonance imaging. Multichannel tES was applied according to personalized biophysical modeling, to maximize the induced electrical field over the solid tumor mass. All patients completed the study and tolerated the procedure without adverse effects, with tES selectively reducing the perfusion of the solid tumor. Results potentially open the door to noninvasive therapeutic interventions in brain tumors based on stand-alone tES or its combination with other available therapies.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Biophysical model ; Brain neoplasms ; Brain perfusion ; Electrical stimulations ; Induced electrical field ; Therapeutic intervention ; Transcranial electrical stimulations ; Tumor perfusion ; Aged ; Antineoplastic Agents ; Brain Neoplasms ; Cerebrovascular Circulation ; Combined Modality Therapy ; Female ; Glioblastoma ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Transcranial Direct Current Stimulation
Publicado en:	Science advances, Vol. 5 Núm. 8 (14 2019) , p. eaau9309, ISSN 2375-2548

DOI: 10.1126/sciadv.aau9309
PMID: 31453319

12 p, 7.2 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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