Facing privacy in neuroimaging : removing facial features degrades performance of image analysis methods
de Sitter, Alexandra (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc)
Visser, M. (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc)
Brouwer, Iman (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc)
Cover, K. S. (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc)
van Schijndel, R. A. (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc)
Eijgelaar, R. S. (The Netherlands Cancer Institute (Amsterdam, Països Baixos))
Müller, D. M. J. (Department of Neurosurgery. Amsterdam UMC. location VUmc)
Ropele, S. (Department of Neurology. Medical University of Graz)
Kappos, Ludwig (University Hospital. Kantonsspital)
Rovira, Alex (Hospital Universitari Vall d'Hebron)
Filippi, Massimo (IRCCS San Raffaele Scientific Institute. Neurorehabilitation Unit)
Enzinger, C. (Division of Neuroradiology. Vascular and Interventional Radiology. Department of Radiology. Medical University of Graz)
Frederiksen, J. (Glostrup University Hospital Copenhagen)
Ciccarelli, Olga (UK/NIHR UCL-UCLH Biomedical Research Centre. Institute of Neurology. UCL)
Guttmann, Charles R. G (Harvard Medical School)
Wattjes, M. P. (Hannover Medical School)
Witte, M. G. (The Netherlands Cancer Institute (Amsterdam, Països Baixos))
de Witt Hamer, P. C. (Department of Neurosurgery. Amsterdam UMC. location VUmc)
Barkhof, Frederik (University College London. Institutes of Neurology & Healthcare Engineering)
Vrenken, Hugo (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Background: Recent studies have created awareness that facial features can be reconstructed from high-resolution MRI. Therefore, data sharing in neuroimaging requires special attention to protect participants' privacy. Facial features removal (FFR) could alleviate these concerns. We assessed the impact of three FFR methods on subsequent automated image analysis to obtain clinically relevant outcome measurements in three clinical groups. Methods: FFR was performed using QuickShear, FaceMasking, and Defacing. In 110 subjects of Alzheimer's Disease Neuroimaging Initiative, normalized brain volumes (NBV) were measured by SIENAX. In 70 multiple sclerosis patients of the MAGNIMS Study Group, lesion volumes (WMLV) were measured by lesion prediction algorithm in lesion segmentation toolbox. In 84 glioblastoma patients of the PICTURE Study Group, tumor volumes (GBV) were measured by BraTumIA. Failed analyses on FFR-processed images were recorded. Only cases in which all image analyses completed successfully were analyzed. Differences between outcomes obtained from FFR-processed and full images were assessed, by quantifying the intra-class correlation coefficient (ICC) for absolute agreement and by testing for systematic differences using paired t tests. Results: Automated analysis methods failed in 0-19% of cases in FFR-processed images versus 0-2% of cases in full images. ICC for absolute agreement ranged from 0. 312 (GBV after FaceMasking) to 0. 998 (WMLV after Defacing). FaceMasking yielded higher NBV (p = 0. 003) and WMLV (p ≤ 0. 001). GBV was lower after QuickShear and Defacing (both p < 0. 001). Conclusions: All three outcome measures were affected differently by FFR, including failure of analysis methods and both "random" variation and systematic differences. Further study is warranted to ensure high-quality neuroimaging research while protecting participants' privacy. Key Points: • Protecting participants' privacy when sharing MRI data is important. • Impact of three facial features removal methods on subsequent analysis was assessed in three clinical groups. • Removing facial features degrades performance of image analysis methods.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Magnetic resonance imaging ; Ethics ; Database ; Neuroimaging ; Privacy
Publicat a:	European Radiology, Vol. 30 Núm. 2 (january 2020) , p. 1062-1074, ISSN 1432-1084

DOI: 10.1007/s00330-019-06459-3
PMID: 31691120

13 p, 3.4 MB

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