Arterial stiffness is highly correlated with the scores obtained from the Steno Type 1 Risk Engine in subjects with T1DM
Llauradó, G. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Cano, Albert (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Albert Fàbregas, Lara (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ballesta Purroy, Sílvia (Institut Hospital del Mar d'Investigacions Mèdiques)
Mazarico, Isabel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Luchtenberg, M. F. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
González-Sastre, Montserrat (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Megía, Ana (Hospital Universitari Joan XXIII de Tarragona)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron)
Vendrell, Joan (Hospital Universitari Joan XXIII de Tarragona)
González-Clemente, José-Miguel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))

Date:	2019
Abstract:	Objectives Currently used risk scores for type 2 diabetes mellitus (T2DM) clearly underestimate cardiovascular risk in type 1 diabetes (T1DM). Hence, there is a need to develop novel and specific risk-estimation tools for this population. We aimed to assess the relationship between the Steno Type 1 Risk Engine (ST1RE) and arterial stiffness (AS), and to identify potential cutoff points of interest in clinical practice. Design and methods A total of 179 patients with T1DM (50. 8% men, mean age 41. 2±13. 1 years), without established cardiovascular disease, were evaluated for clinical and anthropometric data (including classical cardiovascular risk factors), and AS measured by aortic pulse-wave velocity (aPWV). The ST1RE was used to estimate 10-year cardiovascular risk and patients were classified into 3 groups: low- (<10%; n = 105), moderate- (10-20%; n = 53) and high-risk (≥20%; n = 21). Results When compared with the low- and moderate-risk groups, patients in the high-risk group were older, had higher prevalence of hypertension, dyslipidemia and insulin-resistance, and had higher body-mass index and HbA. aPWV increased in parallel with estimated cardiovascular risk (6. 4±1. 0, 8. 4±1. 3 and 10. 3±2. 6m/s; p<0. 001). As an evaluation of model performance, the C-statistic of aPWV was 0. 914 (95% confidence interval [CI]:0. 873-0. 950) for predicting moderate/high-risk and 0. 879 (95%CI:0. 809-0. 948) for high-risk, according to the ST1RE. The best cut-off points of aPWV were 7. 3m/s (sensitivity:86%, specificity:83%) and 8. 7m/s (sensitivity:76%, specificity:86%) for moderate/high- and high-risk, respectively. Conclusions AS is highly correlated with the scores obtained from the ST1RE. We have identified two cut-off points of AS that can clearly discriminate moderate/high- and high-risk T1DM patients, which could be of great value in clinical practice.
Grants:	Instituto de Salud Carlos III PI09-01360 Instituto de Salud Carlos III PI12-00954 Instituto de Salud Carlos III PI15-00567
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adolescent ; Adult ; Aged ; Biomarkers ; Cardiovascular Diseases ; Diabetes Mellitus, Type 1 ; Diabetes Mellitus, Type 2 ; Female ; Humans ; Male ; Microvessels ; Middle Aged ; Pulse Wave Analysis ; ROC Curve ; Vascular Stiffness ; Young Adult
Published in:	PloS one, Vol. 14 Núm. 9 (2019) , p. e0220206, ISSN 1932-6203

DOI: 10.1371/journal.pone.0220206
PMID: 31483791

11 p, 794.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
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Articles > Published articles