Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
Serrano-Novillo, Clara (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
Capera, Jesusa (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
Colomer-Molera, Magalí (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
Condom, Enric (Institut d'Investigació Biomèdica de Bellvitge)
Ferreres Piñas, Joan Carles (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Felipe, Antonio (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)

Date:	2019
Abstract:	Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development.
Grants:	Ministerio de Economía y Competitividad BFU2011-23268 Ministerio de Economía y Competitividad BFU2014-54928-R Ministerio de Economía y Competitividad BFU2017-87104-R
Note:	Altres ajuts: The work carried out by the Molecular Physiology Laboratory was funded by Fondo Europeo de Desarrollo Regional (FEDER). CSN and JC hold fellowships from MINECO and the Fundación Tatiana Pérez de Guzmán el Bueno, respectively.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	K + channels ; Cancer ; Tumor progression ; Cell cycle ; Proliferation
Published in:	Cancers, Vol. 11 (march 2019) , ISSN 2072-6694

DOI: 10.3390/cancers11030287
PMID: 30823672

17 p, 2.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles