Microbiome and colorectal cancer : Roles in carcinogenesis and clinical potential
Saus, Ester (Universitat Pompeu Fabra)
Iraola-Guzmán, Susana (Universitat Pompeu Fabra)
Willis, Jesse R. (Universitat Pompeu Fabra)
Brunet Vega, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Gabaldón, Toni (Institució Catalana de Recerca i Estudis Avançats)

Date:	2019
Abstract:	The gastrointestinal tract harbors most of the microbiota associated with humans. In recent years, there has been a surge of interest in assessing the relationships between the gut microbiota and several gut alterations, including colorectal cancer. Changes in the gut microbiota in patients suffering colorectal cancer suggest a possible role of host-microbe interactions in the origin and development of this malignancy and, at the same time, open the door for novel ways of preventing, diagnosing, or treating this disease. In this review we survey current knowledge on the healthy microbiome of the gut and how it is altered in colorectal cancer and other related disease conditions. In describing past studies we will critically assess technical limitations of different approaches and point to existing challenges in microbiome research. We will have a special focus on host-microbiome interaction mechanisms that may be important to explain how dysbiosis can lead to chronic inflammation and drive processes that influence carcinogenesis and tumor progression in colon cancer. Finally, we will discuss the potential of recent developments of novel microbiota-based therapeutics and diagnostic tools for colorectal cancer.
Grants:	European Commission CA17118 Ministerio de Economía y Competitividad SEV-2012-0208 Ministerio de Economía y Competitividad BFU2015-67107 Agència de Gestió d'Ajuts Universitaris i de Recerca SGR857 European Commission. Horizon 2020 724173 European Commission 642095
Note:	Altres ajuts: Instituto Nacional de Bioinformatica (INB, grant PT17/0009/0023 - ISCIII-SGEFI/ERDF)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Gut microbiome ; Colorectal cancer ; Colon ; Microbiota
Published in:	Molecular Aspects of Medicine, Vol. 69 (october 2019) , p. 93-106, ISSN 1872-9452

DOI: 10.1016/j.mam.2019.05.001
PMID: 31082399

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles