Sleep disturbances and the speed of multimorbidity development in old age : results from a longitudinal population-based study
Sindi, Shireen (Imperial College London. Neuroepidemiology and Ageing Research Unit, School of Public Health)
Pérez, Laura Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vetrano, Davide L. (Centro di Medicina dell'Invecchiamento, IRCCS Fondazione Policlinico "A. Gemelli" and Catholic University of Rome)
Triolo, Federico (Karolinska Institutet and Stockholm University. Aging Research Center, Department of Neurobiology, Care Sciences and Society)
Kåreholt, Ingemar (Jönköping University. Institute of Gerontology, School of Health and Welfare, Aging Research Network - Jönköping (ARN-J))
Sjöberg, Linnea (Karolinska Institutet and Stockholm University. Aging Research Center, Department of Neurobiology, Care Sciences and Society)
Darin-Mattsson, Alexander (Karolinska Institutet and Stockholm University. Aging Research Center, Department of Neurobiology, Care Sciences and Society)
Kivipelto, Miia (Stockholms Sjukhem. Research and Development Unit)
Inzitari, Marco (Universitat Autònoma de Barcelona. Departament de Medicina)
Calderón-Larrañaga, Amaia (Karolinska Institutet and Stockholm University. Aging Research Center, Department of Neurobiology, Care Sciences and Society)

Data:	2020
Resum:	Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate-severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. Moderate-severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß /year = 0. 142, p = 0. 008), regardless of potential confounders. Significant positive associations were also found between moderate-severe sleep disturbances and neuropsychiatric (ß /year = 0. 041, p = 0. 016) and musculoskeletal (ß /year = 0. 038, p = 0. 025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults. The online version contains supplementary material available at 10. 1186/s12916-020-01846-w.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Sleep disturbances ; Multimorbidity ; Aging ; Cardiovascular ; Neuropsychiatric ; Musculoskeletal
Publicat a:	BMC Medicine, Vol. 18 (december 2020) , ISSN 1741-7015

DOI: 10.1186/s12916-020-01846-w
PMID: 33280611

10 p, 611.3 KB

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