The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults
Alonso Cotoner, Carmen (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Abril-Gil, Mar (Hospital Universitari Vall d'Hebron)
Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron)
Mall, John-P. Ganda (Linköping University. Department of Biomedical and Clinical Sciences)
Expósito, Elba (Hospital Universitari Vall d'Hebron)
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron)
Lobo Álvarez, Beatriz (Universitat Autònoma de Barcelona. Facultat de Medicina)
Santos, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)

Fecha:	2021
Resumen:	Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing a variety of chronic diarrheal diseases. In addition to current pharmacological therapies, there is growing interest in alternative products such as mucoprotectants, which form a mucoadhesive film over the epithelium to reduce and protect against the development of altered intestinal permeability, dysbiosis, and mucosal micro-inflammation. This manuscript focuses on chronic diarrhea in adults, and we will review recent evidence on the ability of these natural compounds to improve symptoms associated with chronic diarrhea and to exert protective effects for the intestinal barrier.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució i la comunicació pública de l'obra, sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Adults ; Bismuth subsalicylate ; Chronic diarrhea ; Gelatine tannate ; Mucoprotectans ; Mucus ; Smectite intestinal permeability ; Xyloglugan
Publicado en:	Advances in Therapy, march 2021, p. 1-23, ISSN 1865-8652

DOI: 10.1007/s12325-021-01676-z
PMID: 33738725

23 p, 1.5 MB

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