Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe
Pinato, David J. (Imperial College London. Department of Surgery & Cancer)
Lee, Alvin J. X. (University College London Hospitals)
Biello, Federica (University of Piemonte Orientale)
Seguí, Elia (Hospital Clínic i Provincial de Barcelona)
Aguilar-Company, Juan (Hospital Universitari Vall d'Hebron)
Carbó, Anna (Hospital Universitari de Girona Doctor Josep Trueta)
Bruna, Riccardo (University of Piemonte Orientale)
Bower, Mark (Chelsea & Westminster Hospital)
Rizzo, Gianpiero (Fondazione IRCCS Policlinico San Matteo)
Benafif, Sarah (University College London Hospitals)
Carmona, Carme (Hospital Universitari de Girona Doctor Josep Trueta)
Chopra, Neha (University College London Hospitals)
Cruz, Claudia Andrea (Hospital Clínic i Provincial de Barcelona)
D'avanzo, Francesca (University of Piemonte Orientale)
Evans, Joanne S. (Imperial College London)
Galazi, Myria (University College London Hospitals)
Garcia-Fructuoso, Isabel (Hospital Universitari de Girona Doctor Josep Trueta)
Pria, Alessia D. (Chelsea & Westminster Hospital)
Newsom-Davis, Thomas (Chelsea & Westminster Hospital)
Ottaviani, Diego (University College London Hospitals)
Patriarca, Andrea (University of Piemonte Orientale)
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona)
Sharkey, Rachel (University of Piemonte Orientale)
Sng, Christopher C. T. (University College London Hospitals)
Wong, Yien Ning Sophia (University College London Hospitals)
Ferrante, Daniela (University of Piemonte Orientale)
Scotti, Lorenza (University of Piemonte Orientale)
Avanzi, Gian Carlo (University of Piemonte Orientale)
Bellan, Mattia (University of Piemonte Orientale)
Castello, Luigi Mario (University of Piemonte Orientale)
Marco-Hernández, Javier (Hospital Clínic i Provincial de Barcelona)
Mollà, Meritxell (Hospital Clínic i Provincial de Barcelona)
Pirisi, Mario (University of Piemonte Orientale)
Ruiz-Camps, Isabel (Hospital Universitari Vall d'Hebron)
Sainaghi, Pier Paolo (University of Piemonte Orientale)
Gaidano, Gianluca (University of Piemonte Orientale)
Brunet, Joan (Hospital Universitari de Girona Doctor Josep Trueta)
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia)
Prat, Aleix (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Gennari, Alessandra (University of Piemonte Orientale)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. A total of 127 (62%) were male, 184 (91%) had a diagnosis of solid malignancy, and 103 (51%) had non-metastatic disease. A total of 161 (79%) had > 1 co-morbidity. A total of 141 (69%) patients had > 1 COVID-19 complication. A total of 36 (19%) were escalated to high-dependency or intensive care. A total of 59 (29%) died, 53 (26%) were discharged, and 92 (45%) were in-hospital survivors. Mortality was higher in patients aged > 65 (36% versus 16%), in those with > 2 co-morbidities (40% versus 18%) and developing > 1 complication from COVID-19 (38% versus 4%, p = 0. 004). Multi-variable analyses confirmed age > 65 and > 2 co-morbidities to predict for patient mortality independent of tumor stage, active malignancy, or anticancer therapy. During the early outbreak of SARS-CoV-2 infection in Europe co-morbid burden and advancing age predicted for adverse disease course in cancer patients. The ongoing OnCovid study will allow us to compare risks and outcomes in cancer patients between the initial and later stages of the COVID-19 pandemic.
Nota:	Funding: D.J.P. is supported by grant funding from the Wellcome Trust Strategic Fund (PS3416) and acknowledges grant support by the Cancer Treatment and Research Trust (CTRT) as well as infrastructural support by the Cancer Research UK Imperial Centre. GG is supported by the AIRC 5 × 1000 Grant, No. 21198, Associazione Italiana per la Ricerca sul Cancro Foundation, Milan, Italy. A.G. is supported by the AIRC IG grant, No. 14230, Associazione Italiana per la Ricerca sul Cancro Foundation, Milan, Italy. A.G., G.G., G.C.A., L.M.C., M.B., P.P.S., M.P. from the University of Piemonte Orientale acknowledge support from the UPO Aging Project.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Estudi clínic ; recerca ; Versió publicada
Matèria:	COVID-19 ; Coronavirus ; SARS-CoV-2 ; Cancer ; Survival ; Outcomes ; Mortality
Publicat a:	Cancers, Vol. 12 Núm. 7 (july 2020) , p. 1-13, ISSN 2072-6694

DOI: 10.3390/cancers12071841
PMID: 32650523

14 p, 502.9 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats