MNCD : A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
Santos García, Diego (Hospital San Rafael, A Coruña)
Álvarez Sauco, María (Hospital General Universitario de Elche)
Calopa, Matilde (Hospital Universitari de Bellvitge)
Carrillo, Fátima (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Escamilla Sevilla, Francisco (Hospital Universitario Virgen de las Nieves (Granada))
Freire, Eric (Hospital General Universitario de Elche)
García Ramos, Rocío (Hospital Clínico San Carlos (Madrid))
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Gómez Esteban, Juan Carlos (Hospital Universitario de Cruces (Barakaldo, País Basc))
Legarda, Inés (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Luquin, Maria-Rosario (Clínica Universidad de Navarra)
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Martínez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Martínez-Torres, Irene (Hospital Universitari i Politècnic La Fe (València))
Mir, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Ignacio, Ángel Sesar (Complejo Hospitalario Universitario de Santiago de Compostela)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	Background and objective : Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods : Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results : The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions : A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.
Ayudas:	Ministerio de Economía, Industria y Competitividad PI16/01575
Nota:	Altres ajuts: Research funding: Roche, Zambon: Ciberned; Instituto de Salud Carlos III; Fundació La Maratóde TV3.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cognition ; Dependency ; Non-motor symptoms ; Motor symptoms ; Parkinson's disease
Publicado en:	Diagnostics, Vol. 12 (december 2021) , ISSN 2075-4418

DOI: 10.3390/diagnostics12010055
PMID: 35054222

14 p, 3.0 MB

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