The neurobiological basis of cognitive side effects of electroconvulsive therapy : a systematic review
Bassa, Adriana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Sagués, Teresa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Porta-Casteràs, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Serra, Pilar (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Martínez-Amorós, Erika (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Palao, Diego (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Cano, Marta (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Cardoner, N. (Narcís) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Date:	2021
Abstract:	Decades of research have consistently demonstrated the efficacy of electroconvulsive therapy (ECT) for the treatment of major depressive disorder (MDD), but its clinical use remains somewhat restricted because of its cognitive side effects. The aim of this systematic review is to comprehensively summarize current evidence assessing potential biomarkers of ECT-related cognitive side effects. Based on our systematic search of human studies indexed in PubMed, Scopus, and Web of Knowledge, a total of 29 studies evaluating patients with MDD undergoing ECT were reviewed. Molecular biomarkers studies did not consistently identify concentration changes in plasma S-100 protein, neuron-specific enolase (NSE), or Aβ peptides significantly associated with cognitive performance after ECT. Importantly, these findings suggest that ECT-related cognitive side effects cannot be explained by mechanisms of neural cell damage. Notwithstanding, S-100b protein and Aβ40 peptide concentrations, as well as brain-derived neurotrophic factor (BDNF) polymorphisms, have been suggested as potential predictive biomarkers of cognitive dysfunction after ECT. In addition, recent advances in brain imaging have allowed us to identify ECT-induced volumetric and functional changes in several brain structures closely related to memory performance such as the hippocampus. We provide a preliminary framework to further evaluate neurobiological cognitive vulnerability profiles of patients with MDD treated with ECT.
Grants:	Instituto de Salud Carlos III FI19/00251 Instituto de Salud Carlos III PI18/00036
Note:	Altres ajuts: M.C. is founded by the Sara Borrell postdoctoral contract [CD20/00189].
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Electroconvulsive therapy ; ECT ; Memory ; Cognitive impairment ; Side effects ; MDD ; Biomarkers ; Hippocampus ; NSE ; S-100
Published in:	Brain sciences, Vol. 11 Núm. 10 (october 2021) , p. 1273, ISSN 2076-3425

DOI: 10.3390/brainsci11101273
PMID: 34679338

14 p, 511.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles