Low birth weight as a potential risk factor for severe COVID-19 in adults
Crispi, Fatima (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Crovetto, Francesca (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Larroya, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Camacho, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Tortajada, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Sibila, Oriol (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Badia, Joan Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
López, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Vellvé, Kilian (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Garcia, Ferran (Hospital Clínic i Provincial de Barcelona)
Trilla, Antoni (Hospital Clínic i Provincial de Barcelona)
Faner, Rosa (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Blanco, Isabel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Borràs, Roger (Universitat Autònoma de Barcelona)
Agustí, Àlvar (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Gratacos, Eduard (Institut d'Investigacions Biomèdiques August Pi i Sunyer)

Data:	2021
Resum:	The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2. 500 g. Age (adjusted OR (aOR) 1. 04 [1-1. 07], P = 0. 012), male sex (aOR 3. 39 [1. 72-6. 67], P < 0. 001), hypertension (aOR 3. 37 [1. 69-6. 72], P = 0. 001), and LBW (aOR 3. 61 [1. 55-8. 43], P = 0. 003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0. 79 [95% CI, 0. 74-0. 85], with positive and negative predictive values of 29. 1% and 97. 6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2. 5%) needed ICU admission (AUC 0. 74 [95% CI 0. 68-0. 81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Viral infection ; Reproductive disorders
Publicat a:	Scientific reports, Vol. 11 (february 2021) , ISSN 2045-2322

DOI: 10.1038/s41598-021-82389-9
PMID: 33536488

8 p, 1.1 MB

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